Mechanism of Protein Aggregation Inhibition by Arginine: Blockage of Anionic Side Chains Favors Unproductive Encounter Complexes

Aggregation refers to the assembly of proteins into nonphysiological higher order structures. While amyloid has been studied extensively, much less is known about amorphous aggregation, a process that interferes with protein expression and storage. Free arginine (Arg+) is a widely used aggregation i...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-03, Vol.146 (12), p.8394-8406
Hauptverfasser:	Ng, Yuen Ki, Konermann, Lars
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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