Host cell proteins in monoclonal antibody processing: Control, detection, and removal

Host cell proteins (HCPs) are process‐related impurities in a therapeutic protein expressed using cell culture technology. This review presents biopharmaceutical industry trends in terms of both HCPs in the bioprocessing of monoclonal antibodies (mAbs) and the capabilities for HCP clearance by downs...

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Veröffentlicht in:	Biotechnology progress 2024-07, Vol.40 (4), p.e3448-n/a
Hauptverfasser:	Ito, Takao, Lutz, Herb, Tan, Lihan, Wang, Bin, Tan, Janice, Patel, Masum, Chen, Lance, Tsunakawa, Yuki, Park, Byunghyun, Banerjee, Subhasis
Format:	Artikel
Sprache:	eng
Schlagworte:	Batch processing Best practice Bioprocessing Cell culture Cell density Clearances continuous bioprocessing downstream process host cell protein Impurities Manufacturing Manufacturing industry Meta-analysis Monoclonal antibodies monoclonal antibody Proteins Trends
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