Human Campylobacter spp. infections in Italy
Purpose Campylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2024-05, Vol.43 (5), p.895-904 |
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| creator | Zerbato, Verena Di Bella, Stefano Pol, Riccardo Luzzati, Roberto Sanson, Gianfranco Ambretti, Simone Andreoni, Stefano Aschbacher, Richard Bernardo, Mariano Bielli, Alessandra Brigante, Gioconda Busetti, Marina Camarlinghi, Giulio Carcione, Davide Carducci, Antonella Clementi, Nicola Carretto, Edoardo Chilleri, Chiara Codda, Giulia Consonni, Alessandra Costantino, Venera Cortazzo, Venere Di Santolo, Manuela Dodaro, Saveria Fiori, Barbara García-Fernández, Aurora Foschi, Claudio Gobbato, Elisa Greco, Francesca La Ragione, Roberto Marcello Mancini, Nicasio Maraolo, Alberto Enrico Marchese, Anna Marcuccio, Daniela Marrollo, Roberta Mauri, Carola Mazzariol, Annarita Morroni, Gianluca Mosca, Adriana Nigrisoli, Giacomo Pagani, Elisabetta Parisio, Eva Maria Pollini, Simona Sarti, Mario Sorrentino, Annarita Trotta, Domenico Villa, Laura Vismara, Chiara Principe, Luigi |
| description | Purpose
Campylobacter
is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human
Campylobacter
infections in Italy during the period 2017–2021.
Methods
Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results
In total, 5419 isolations of
Campylobacter
spp. were performed. The most common species were
C. jejuni
(n = 4535, 83.7%), followed by
C. coli
(n = 732, 13.5%) and
C. fetus
(n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected.
Campylobacter
were isolated from faeces in 97.3% of cases and in 2.7% from blood.
C. fetus
was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of
C. jejuni
and
C. coli
were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p |
| doi_str_mv | 10.1007/s10096-024-04803-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2956681579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2956681579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-8eccb0c6d4b002b1eb7c00b27a8adc963c2445fda9a5abc2e034e0f4fe6b78a3</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EoqXwBxhQJBYGUl78GY-oAlqpEkt3y3YclCpf2MnQf48hBSQGFj9L79xr6yB0ncEyAxAPIZ6Sp4BpCjQHksIJmmeUsJQSQU7RHCShqRSYzNBFCHuIoVyIczQjORWYYTxH9-ux0W2y0k1_qDuj7eB8Evp-mVRt6exQdW2I12Qz6Ppwic5KXQd3dZwLtHt-2q3W6fb1ZbN63KaWYD6kubPWgOUFNQDYZM4IC2Cw0LkurOTEYkpZWWipmTYWOyDUQUlLx43INVmgu6m299376MKgmipYV9e6dd0YFJaM8zxjQkb09g-670bfxs8pAkxETnIWKTxR1ncheFeq3leN9geVgfpUqSaVKqpUXyoVxNDNsXo0jSt-It_uIkAmIMRV--b879v_1H4ALtB9fA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3057566965</pqid></control><display><type>article</type><title>Human Campylobacter spp. infections in Italy</title><source>MEDLINE</source><source>SpringerLink</source><creator>Zerbato, Verena ; Di Bella, Stefano ; Pol, Riccardo ; Luzzati, Roberto ; Sanson, Gianfranco ; Ambretti, Simone ; Andreoni, Stefano ; Aschbacher, Richard ; Bernardo, Mariano ; Bielli, Alessandra ; Brigante, Gioconda ; Busetti, Marina ; Camarlinghi, Giulio ; Carcione, Davide ; Carducci, Antonella ; Clementi, Nicola ; Carretto, Edoardo ; Chilleri, Chiara ; Codda, Giulia ; Consonni, Alessandra ; Costantino, Venera ; Cortazzo, Venere ; Di Santolo, Manuela ; Dodaro, Saveria ; Fiori, Barbara ; García-Fernández, Aurora ; Foschi, Claudio ; Gobbato, Elisa ; Greco, Francesca ; La Ragione, Roberto Marcello ; Mancini, Nicasio ; Maraolo, Alberto Enrico ; Marchese, Anna ; Marcuccio, Daniela ; Marrollo, Roberta ; Mauri, Carola ; Mazzariol, Annarita ; Morroni, Gianluca ; Mosca, Adriana ; Nigrisoli, Giacomo ; Pagani, Elisabetta ; Parisio, Eva Maria ; Pollini, Simona ; Sarti, Mario ; Sorrentino, Annarita ; Trotta, Domenico ; Villa, Laura ; Vismara, Chiara ; Principe, Luigi</creator><creatorcontrib>Zerbato, Verena ; Di Bella, Stefano ; Pol, Riccardo ; Luzzati, Roberto ; Sanson, Gianfranco ; Ambretti, Simone ; Andreoni, Stefano ; Aschbacher, Richard ; Bernardo, Mariano ; Bielli, Alessandra ; Brigante, Gioconda ; Busetti, Marina ; Camarlinghi, Giulio ; Carcione, Davide ; Carducci, Antonella ; Clementi, Nicola ; Carretto, Edoardo ; Chilleri, Chiara ; Codda, Giulia ; Consonni, Alessandra ; Costantino, Venera ; Cortazzo, Venere ; Di Santolo, Manuela ; Dodaro, Saveria ; Fiori, Barbara ; García-Fernández, Aurora ; Foschi, Claudio ; Gobbato, Elisa ; Greco, Francesca ; La Ragione, Roberto Marcello ; Mancini, Nicasio ; Maraolo, Alberto Enrico ; Marchese, Anna ; Marcuccio, Daniela ; Marrollo, Roberta ; Mauri, Carola ; Mazzariol, Annarita ; Morroni, Gianluca ; Mosca, Adriana ; Nigrisoli, Giacomo ; Pagani, Elisabetta ; Parisio, Eva Maria ; Pollini, Simona ; Sarti, Mario ; Sorrentino, Annarita ; Trotta, Domenico ; Villa, Laura ; Vismara, Chiara ; Principe, Luigi</creatorcontrib><description>Purpose
Campylobacter
is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human
Campylobacter
infections in Italy during the period 2017–2021.
Methods
Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results
In total, 5419 isolations of
Campylobacter
spp. were performed. The most common species were
C. jejuni
(n = 4535, 83.7%), followed by
C. coli
(n = 732, 13.5%) and
C. fetus
(n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected.
Campylobacter
were isolated from faeces in 97.3% of cases and in 2.7% from blood.
C. fetus
was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of
C. jejuni
and
C. coli
were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
Conclusion
Campylobacter
resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-024-04803-0</identifier><identifier>PMID: 38472522</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Antimicrobial resistance ; Azithromycin ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Campylobacter ; Campylobacter - drug effects ; Campylobacter - isolation & purification ; Campylobacter Infections - epidemiology ; Campylobacter Infections - microbiology ; Campylobacter jejuni - drug effects ; Campylobacter jejuni - isolation & purification ; Campylobacteriosis ; Child ; Child, Preschool ; Ciprofloxacin ; Clarithromycin ; Drug Resistance, Bacterial ; Epidemiology ; Erythromycin ; Feces - microbiology ; Female ; Fetuses ; Fluoroquinolones ; Humans ; Infant ; Infant, Newborn ; Infections ; Internal Medicine ; Italy - epidemiology ; Male ; Mass spectrometry ; Mass spectroscopy ; Medical Microbiology ; Microbial Sensitivity Tests ; Middle Aged ; Original Article ; Tetracyclines ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2024-05, Vol.43 (5), p.895-904</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-8eccb0c6d4b002b1eb7c00b27a8adc963c2445fda9a5abc2e034e0f4fe6b78a3</cites><orcidid>0000-0002-9204-032X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-024-04803-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-024-04803-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38472522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zerbato, Verena</creatorcontrib><creatorcontrib>Di Bella, Stefano</creatorcontrib><creatorcontrib>Pol, Riccardo</creatorcontrib><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Sanson, Gianfranco</creatorcontrib><creatorcontrib>Ambretti, Simone</creatorcontrib><creatorcontrib>Andreoni, Stefano</creatorcontrib><creatorcontrib>Aschbacher, Richard</creatorcontrib><creatorcontrib>Bernardo, Mariano</creatorcontrib><creatorcontrib>Bielli, Alessandra</creatorcontrib><creatorcontrib>Brigante, Gioconda</creatorcontrib><creatorcontrib>Busetti, Marina</creatorcontrib><creatorcontrib>Camarlinghi, Giulio</creatorcontrib><creatorcontrib>Carcione, Davide</creatorcontrib><creatorcontrib>Carducci, Antonella</creatorcontrib><creatorcontrib>Clementi, Nicola</creatorcontrib><creatorcontrib>Carretto, Edoardo</creatorcontrib><creatorcontrib>Chilleri, Chiara</creatorcontrib><creatorcontrib>Codda, Giulia</creatorcontrib><creatorcontrib>Consonni, Alessandra</creatorcontrib><creatorcontrib>Costantino, Venera</creatorcontrib><creatorcontrib>Cortazzo, Venere</creatorcontrib><creatorcontrib>Di Santolo, Manuela</creatorcontrib><creatorcontrib>Dodaro, Saveria</creatorcontrib><creatorcontrib>Fiori, Barbara</creatorcontrib><creatorcontrib>García-Fernández, Aurora</creatorcontrib><creatorcontrib>Foschi, Claudio</creatorcontrib><creatorcontrib>Gobbato, Elisa</creatorcontrib><creatorcontrib>Greco, Francesca</creatorcontrib><creatorcontrib>La Ragione, Roberto Marcello</creatorcontrib><creatorcontrib>Mancini, Nicasio</creatorcontrib><creatorcontrib>Maraolo, Alberto Enrico</creatorcontrib><creatorcontrib>Marchese, Anna</creatorcontrib><creatorcontrib>Marcuccio, Daniela</creatorcontrib><creatorcontrib>Marrollo, Roberta</creatorcontrib><creatorcontrib>Mauri, Carola</creatorcontrib><creatorcontrib>Mazzariol, Annarita</creatorcontrib><creatorcontrib>Morroni, Gianluca</creatorcontrib><creatorcontrib>Mosca, Adriana</creatorcontrib><creatorcontrib>Nigrisoli, Giacomo</creatorcontrib><creatorcontrib>Pagani, Elisabetta</creatorcontrib><creatorcontrib>Parisio, Eva Maria</creatorcontrib><creatorcontrib>Pollini, Simona</creatorcontrib><creatorcontrib>Sarti, Mario</creatorcontrib><creatorcontrib>Sorrentino, Annarita</creatorcontrib><creatorcontrib>Trotta, Domenico</creatorcontrib><creatorcontrib>Villa, Laura</creatorcontrib><creatorcontrib>Vismara, Chiara</creatorcontrib><creatorcontrib>Principe, Luigi</creatorcontrib><title>Human Campylobacter spp. infections in Italy</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Purpose
Campylobacter
is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human
Campylobacter
infections in Italy during the period 2017–2021.
Methods
Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results
In total, 5419 isolations of
Campylobacter
spp. were performed. The most common species were
C. jejuni
(n = 4535, 83.7%), followed by
C. coli
(n = 732, 13.5%) and
C. fetus
(n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected.
Campylobacter
were isolated from faeces in 97.3% of cases and in 2.7% from blood.
C. fetus
was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of
C. jejuni
and
C. coli
were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
Conclusion
Campylobacter
resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Azithromycin</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Campylobacter</subject><subject>Campylobacter - drug effects</subject><subject>Campylobacter - isolation & purification</subject><subject>Campylobacter Infections - epidemiology</subject><subject>Campylobacter Infections - microbiology</subject><subject>Campylobacter jejuni - drug effects</subject><subject>Campylobacter jejuni - isolation & purification</subject><subject>Campylobacteriosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ciprofloxacin</subject><subject>Clarithromycin</subject><subject>Drug Resistance, Bacterial</subject><subject>Epidemiology</subject><subject>Erythromycin</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Fluoroquinolones</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Tetracyclines</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqXwBxhQJBYGUl78GY-oAlqpEkt3y3YclCpf2MnQf48hBSQGFj9L79xr6yB0ncEyAxAPIZ6Sp4BpCjQHksIJmmeUsJQSQU7RHCShqRSYzNBFCHuIoVyIczQjORWYYTxH9-ux0W2y0k1_qDuj7eB8Evp-mVRt6exQdW2I12Qz6Ppwic5KXQd3dZwLtHt-2q3W6fb1ZbN63KaWYD6kubPWgOUFNQDYZM4IC2Cw0LkurOTEYkpZWWipmTYWOyDUQUlLx43INVmgu6m299376MKgmipYV9e6dd0YFJaM8zxjQkb09g-670bfxs8pAkxETnIWKTxR1ncheFeq3leN9geVgfpUqSaVKqpUXyoVxNDNsXo0jSt-It_uIkAmIMRV--b879v_1H4ALtB9fA</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Zerbato, Verena</creator><creator>Di Bella, Stefano</creator><creator>Pol, Riccardo</creator><creator>Luzzati, Roberto</creator><creator>Sanson, Gianfranco</creator><creator>Ambretti, Simone</creator><creator>Andreoni, Stefano</creator><creator>Aschbacher, Richard</creator><creator>Bernardo, Mariano</creator><creator>Bielli, Alessandra</creator><creator>Brigante, Gioconda</creator><creator>Busetti, Marina</creator><creator>Camarlinghi, Giulio</creator><creator>Carcione, Davide</creator><creator>Carducci, Antonella</creator><creator>Clementi, Nicola</creator><creator>Carretto, Edoardo</creator><creator>Chilleri, Chiara</creator><creator>Codda, Giulia</creator><creator>Consonni, Alessandra</creator><creator>Costantino, Venera</creator><creator>Cortazzo, Venere</creator><creator>Di Santolo, Manuela</creator><creator>Dodaro, Saveria</creator><creator>Fiori, Barbara</creator><creator>García-Fernández, Aurora</creator><creator>Foschi, Claudio</creator><creator>Gobbato, Elisa</creator><creator>Greco, Francesca</creator><creator>La Ragione, Roberto Marcello</creator><creator>Mancini, Nicasio</creator><creator>Maraolo, Alberto Enrico</creator><creator>Marchese, Anna</creator><creator>Marcuccio, Daniela</creator><creator>Marrollo, Roberta</creator><creator>Mauri, Carola</creator><creator>Mazzariol, Annarita</creator><creator>Morroni, Gianluca</creator><creator>Mosca, Adriana</creator><creator>Nigrisoli, Giacomo</creator><creator>Pagani, Elisabetta</creator><creator>Parisio, Eva Maria</creator><creator>Pollini, Simona</creator><creator>Sarti, Mario</creator><creator>Sorrentino, Annarita</creator><creator>Trotta, Domenico</creator><creator>Villa, Laura</creator><creator>Vismara, Chiara</creator><creator>Principe, Luigi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9204-032X</orcidid></search><sort><creationdate>20240501</creationdate><title>Human Campylobacter spp. infections in Italy</title><author>Zerbato, Verena ; Di Bella, Stefano ; Pol, Riccardo ; Luzzati, Roberto ; Sanson, Gianfranco ; Ambretti, Simone ; Andreoni, Stefano ; Aschbacher, Richard ; Bernardo, Mariano ; Bielli, Alessandra ; Brigante, Gioconda ; Busetti, Marina ; Camarlinghi, Giulio ; Carcione, Davide ; Carducci, Antonella ; Clementi, Nicola ; Carretto, Edoardo ; Chilleri, Chiara ; Codda, Giulia ; Consonni, Alessandra ; Costantino, Venera ; Cortazzo, Venere ; Di Santolo, Manuela ; Dodaro, Saveria ; Fiori, Barbara ; García-Fernández, Aurora ; Foschi, Claudio ; Gobbato, Elisa ; Greco, Francesca ; La Ragione, Roberto Marcello ; Mancini, Nicasio ; Maraolo, Alberto Enrico ; Marchese, Anna ; Marcuccio, Daniela ; Marrollo, Roberta ; Mauri, Carola ; Mazzariol, Annarita ; Morroni, Gianluca ; Mosca, Adriana ; Nigrisoli, Giacomo ; Pagani, Elisabetta ; Parisio, Eva Maria ; Pollini, Simona ; Sarti, Mario ; Sorrentino, Annarita ; Trotta, Domenico ; Villa, Laura ; Vismara, Chiara ; Principe, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-8eccb0c6d4b002b1eb7c00b27a8adc963c2445fda9a5abc2e034e0f4fe6b78a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Azithromycin</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Campylobacter</topic><topic>Campylobacter - drug effects</topic><topic>Campylobacter - isolation & purification</topic><topic>Campylobacter Infections - epidemiology</topic><topic>Campylobacter Infections - microbiology</topic><topic>Campylobacter jejuni - drug effects</topic><topic>Campylobacter jejuni - isolation & purification</topic><topic>Campylobacteriosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ciprofloxacin</topic><topic>Clarithromycin</topic><topic>Drug Resistance, Bacterial</topic><topic>Epidemiology</topic><topic>Erythromycin</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Fluoroquinolones</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical Microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Tetracyclines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zerbato, Verena</creatorcontrib><creatorcontrib>Di Bella, Stefano</creatorcontrib><creatorcontrib>Pol, Riccardo</creatorcontrib><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Sanson, Gianfranco</creatorcontrib><creatorcontrib>Ambretti, Simone</creatorcontrib><creatorcontrib>Andreoni, Stefano</creatorcontrib><creatorcontrib>Aschbacher, Richard</creatorcontrib><creatorcontrib>Bernardo, Mariano</creatorcontrib><creatorcontrib>Bielli, Alessandra</creatorcontrib><creatorcontrib>Brigante, Gioconda</creatorcontrib><creatorcontrib>Busetti, Marina</creatorcontrib><creatorcontrib>Camarlinghi, Giulio</creatorcontrib><creatorcontrib>Carcione, Davide</creatorcontrib><creatorcontrib>Carducci, Antonella</creatorcontrib><creatorcontrib>Clementi, Nicola</creatorcontrib><creatorcontrib>Carretto, Edoardo</creatorcontrib><creatorcontrib>Chilleri, Chiara</creatorcontrib><creatorcontrib>Codda, Giulia</creatorcontrib><creatorcontrib>Consonni, Alessandra</creatorcontrib><creatorcontrib>Costantino, Venera</creatorcontrib><creatorcontrib>Cortazzo, Venere</creatorcontrib><creatorcontrib>Di Santolo, Manuela</creatorcontrib><creatorcontrib>Dodaro, Saveria</creatorcontrib><creatorcontrib>Fiori, Barbara</creatorcontrib><creatorcontrib>García-Fernández, Aurora</creatorcontrib><creatorcontrib>Foschi, Claudio</creatorcontrib><creatorcontrib>Gobbato, Elisa</creatorcontrib><creatorcontrib>Greco, Francesca</creatorcontrib><creatorcontrib>La Ragione, Roberto Marcello</creatorcontrib><creatorcontrib>Mancini, Nicasio</creatorcontrib><creatorcontrib>Maraolo, Alberto Enrico</creatorcontrib><creatorcontrib>Marchese, Anna</creatorcontrib><creatorcontrib>Marcuccio, Daniela</creatorcontrib><creatorcontrib>Marrollo, Roberta</creatorcontrib><creatorcontrib>Mauri, Carola</creatorcontrib><creatorcontrib>Mazzariol, Annarita</creatorcontrib><creatorcontrib>Morroni, Gianluca</creatorcontrib><creatorcontrib>Mosca, Adriana</creatorcontrib><creatorcontrib>Nigrisoli, Giacomo</creatorcontrib><creatorcontrib>Pagani, Elisabetta</creatorcontrib><creatorcontrib>Parisio, Eva Maria</creatorcontrib><creatorcontrib>Pollini, Simona</creatorcontrib><creatorcontrib>Sarti, Mario</creatorcontrib><creatorcontrib>Sorrentino, Annarita</creatorcontrib><creatorcontrib>Trotta, Domenico</creatorcontrib><creatorcontrib>Villa, Laura</creatorcontrib><creatorcontrib>Vismara, Chiara</creatorcontrib><creatorcontrib>Principe, Luigi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zerbato, Verena</au><au>Di Bella, Stefano</au><au>Pol, Riccardo</au><au>Luzzati, Roberto</au><au>Sanson, Gianfranco</au><au>Ambretti, Simone</au><au>Andreoni, Stefano</au><au>Aschbacher, Richard</au><au>Bernardo, Mariano</au><au>Bielli, Alessandra</au><au>Brigante, Gioconda</au><au>Busetti, Marina</au><au>Camarlinghi, Giulio</au><au>Carcione, Davide</au><au>Carducci, Antonella</au><au>Clementi, Nicola</au><au>Carretto, Edoardo</au><au>Chilleri, Chiara</au><au>Codda, Giulia</au><au>Consonni, Alessandra</au><au>Costantino, Venera</au><au>Cortazzo, Venere</au><au>Di Santolo, Manuela</au><au>Dodaro, Saveria</au><au>Fiori, Barbara</au><au>García-Fernández, Aurora</au><au>Foschi, Claudio</au><au>Gobbato, Elisa</au><au>Greco, Francesca</au><au>La Ragione, Roberto Marcello</au><au>Mancini, Nicasio</au><au>Maraolo, Alberto Enrico</au><au>Marchese, Anna</au><au>Marcuccio, Daniela</au><au>Marrollo, Roberta</au><au>Mauri, Carola</au><au>Mazzariol, Annarita</au><au>Morroni, Gianluca</au><au>Mosca, Adriana</au><au>Nigrisoli, Giacomo</au><au>Pagani, Elisabetta</au><au>Parisio, Eva Maria</au><au>Pollini, Simona</au><au>Sarti, Mario</au><au>Sorrentino, Annarita</au><au>Trotta, Domenico</au><au>Villa, Laura</au><au>Vismara, Chiara</au><au>Principe, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Campylobacter spp. infections in Italy</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>43</volume><issue>5</issue><spage>895</spage><epage>904</epage><pages>895-904</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Purpose
Campylobacter
is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human
Campylobacter
infections in Italy during the period 2017–2021.
Methods
Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results
In total, 5419 isolations of
Campylobacter
spp. were performed. The most common species were
C. jejuni
(n = 4535, 83.7%), followed by
C. coli
(n = 732, 13.5%) and
C. fetus
(n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected.
Campylobacter
were isolated from faeces in 97.3% of cases and in 2.7% from blood.
C. fetus
was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of
C. jejuni
and
C. coli
were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
Conclusion
Campylobacter
resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38472522</pmid><doi>10.1007/s10096-024-04803-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9204-032X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2024-05, Vol.43 (5), p.895-904 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2956681579 |
| source | MEDLINE; SpringerLink |
| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Antimicrobial resistance Azithromycin Biomedical and Life Sciences Biomedicine Blood Campylobacter Campylobacter - drug effects Campylobacter - isolation & purification Campylobacter Infections - epidemiology Campylobacter Infections - microbiology Campylobacter jejuni - drug effects Campylobacter jejuni - isolation & purification Campylobacteriosis Child Child, Preschool Ciprofloxacin Clarithromycin Drug Resistance, Bacterial Epidemiology Erythromycin Feces - microbiology Female Fetuses Fluoroquinolones Humans Infant Infant, Newborn Infections Internal Medicine Italy - epidemiology Male Mass spectrometry Mass spectroscopy Medical Microbiology Microbial Sensitivity Tests Middle Aged Original Article Tetracyclines Young Adult |
| title | Human Campylobacter spp. infections in Italy |
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