Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism

Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease with current treatments marred by severe side effects or delivery issues. To identify novel classes of compounds for the treatment of HAT, high throughput screening (HTS) had previously been conducted on blood...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-03, Vol.268, p.116162-116162, Article 116162
Hauptverfasser:	Varghese, Swapna, Srivastava, Anubhav, Wong, Siu Wai, Le, Thuy, Pitcher, Noel, Mesnard, Mathilda, Lallemand, Camille, Rahmani, Raphael, Moawad, Sarah R., Huang, Fei, He, Tiantong, Sleebs, Brad E., Barrett, Michael P., Sykes, Melissa L., Avery, Vicky M., Creek, Darren J., Baell, Jonathan B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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