Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition
Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of nicaraven to attenuate cancer radioresistance during fractionated radiotherapy. Tumor models were established in C57BL/6 mice and BALB/c nude mice by sub...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2025, Vol.480 (1), p.341-353 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 353 |
|---|---|
| container_issue | 1 |
| container_start_page | 341 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 480 |
| creator | Huang, Kai Yan, Chen Abdelghany, Lina Zhang, Xu Jingu, Keiichi Li, Tao-Sheng |
| description | Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of nicaraven to attenuate cancer radioresistance during fractionated radiotherapy. Tumor models were established in C57BL/6 mice and BALB/c nude mice by subcutaneous injection of Lewis mouse lung carcinoma cancer cells and A549 human lung cancer cells, respectively. When the tumors had grown to approximately 100 mm
3
, we initiated fractionated radiotherapy. Nicaraven or saline was administered immediately after each irradiation exposure. Compared to saline treatment, nicaraven administration significantly induced gamma-H2AX foci formation and cell apoptosis in tumors at 1 or 3 days after an additional challenge exposure to 10 Gy and inhibited tumor growth during the short-term follow-up period, suggesting increased radiosensitivity of cancer cells. Moreover, the expression of PARP in tumor tissue was decreased by nicaraven administration. Our data suggest that nicaraven likely attenuates the acquired radioresistance of cancers through PARP inhibition. |
| doi_str_mv | 10.1007/s11010-024-04958-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2956161848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2956161848</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-e841cbee51b3005ca0f74acc3ab5d31535739dd2fa00f4bb8b12259d979c783f3</originalsourceid><addsrcrecordid>eNp9kEtLxTAQhYMoer36B1xIlm6qmSZtk6WILxC9iK5Dkk690T40aQX_vdGqSzeZwDlzOPMRcgDsGBirTiIAA5axXGRMqEJm5QZZQFHxTChQm2TBOGOZhKraIbsxPrPkZgDbZIdLUZairBbk5dY7E8w79tSMI_aTGTHScY3UuLfJB6xpMLUfAkYfR9M7pENDMX1t6-M6yePUDSFS39NumCKmt8Y20ndv6Or0fpWEtbd-9EO_R7Ya00bc_5lL8nhx_nB2ld3cXV6fnd5kLldyzFAKcBaxAJv6F86wphLGOW5sUXMoeLpQ1XXeGMYaYa20kOeFqlWlXCV5w5fkaM59DcPblLrqzkeHbWt6TBV1rooSSpBCJms-W10YYgzY6NfgOxM-NDD9BVnPkHWCrL8h6zItHf7kT7bD-m_ll2oy8NkQk9Q_YdDPwxT6dPN_sZ-UL4lg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2956161848</pqid></control><display><type>article</type><title>Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Huang, Kai ; Yan, Chen ; Abdelghany, Lina ; Zhang, Xu ; Jingu, Keiichi ; Li, Tao-Sheng</creator><creatorcontrib>Huang, Kai ; Yan, Chen ; Abdelghany, Lina ; Zhang, Xu ; Jingu, Keiichi ; Li, Tao-Sheng</creatorcontrib><description>Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of nicaraven to attenuate cancer radioresistance during fractionated radiotherapy. Tumor models were established in C57BL/6 mice and BALB/c nude mice by subcutaneous injection of Lewis mouse lung carcinoma cancer cells and A549 human lung cancer cells, respectively. When the tumors had grown to approximately 100 mm
3
, we initiated fractionated radiotherapy. Nicaraven or saline was administered immediately after each irradiation exposure. Compared to saline treatment, nicaraven administration significantly induced gamma-H2AX foci formation and cell apoptosis in tumors at 1 or 3 days after an additional challenge exposure to 10 Gy and inhibited tumor growth during the short-term follow-up period, suggesting increased radiosensitivity of cancer cells. Moreover, the expression of PARP in tumor tissue was decreased by nicaraven administration. Our data suggest that nicaraven likely attenuates the acquired radioresistance of cancers through PARP inhibition.</description><identifier>ISSN: 0300-8177</identifier><identifier>ISSN: 1573-4919</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-024-04958-6</identifier><identifier>PMID: 38466467</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>A549 Cells ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Cancer Research ; Carcinoma, Lewis Lung - drug therapy ; Carcinoma, Lewis Lung - pathology ; Carcinoma, Lewis Lung - radiotherapy ; Cardiology ; Cell Line, Tumor ; Humans ; Life Sciences ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lung Neoplasms - radiotherapy ; Medical Biochemistry ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology ; Poly(ADP-ribose) Polymerases - metabolism ; Radiation Tolerance - drug effects</subject><ispartof>Molecular and cellular biochemistry, 2025, Vol.480 (1), p.341-353</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-e841cbee51b3005ca0f74acc3ab5d31535739dd2fa00f4bb8b12259d979c783f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-024-04958-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-024-04958-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38466467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><creatorcontrib>Abdelghany, Lina</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Jingu, Keiichi</creatorcontrib><creatorcontrib>Li, Tao-Sheng</creatorcontrib><title>Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of nicaraven to attenuate cancer radioresistance during fractionated radiotherapy. Tumor models were established in C57BL/6 mice and BALB/c nude mice by subcutaneous injection of Lewis mouse lung carcinoma cancer cells and A549 human lung cancer cells, respectively. When the tumors had grown to approximately 100 mm
3
, we initiated fractionated radiotherapy. Nicaraven or saline was administered immediately after each irradiation exposure. Compared to saline treatment, nicaraven administration significantly induced gamma-H2AX foci formation and cell apoptosis in tumors at 1 or 3 days after an additional challenge exposure to 10 Gy and inhibited tumor growth during the short-term follow-up period, suggesting increased radiosensitivity of cancer cells. Moreover, the expression of PARP in tumor tissue was decreased by nicaraven administration. Our data suggest that nicaraven likely attenuates the acquired radioresistance of cancers through PARP inhibition.</description><subject>A549 Cells</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Carcinoma, Lewis Lung - drug therapy</subject><subject>Carcinoma, Lewis Lung - pathology</subject><subject>Carcinoma, Lewis Lung - radiotherapy</subject><subject>Cardiology</subject><subject>Cell Line, Tumor</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Medical Biochemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Nude</subject><subject>Poly(ADP-ribose) Polymerase Inhibitors - pharmacology</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Radiation Tolerance - drug effects</subject><issn>0300-8177</issn><issn>1573-4919</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxTAQhYMoer36B1xIlm6qmSZtk6WILxC9iK5Dkk690T40aQX_vdGqSzeZwDlzOPMRcgDsGBirTiIAA5axXGRMqEJm5QZZQFHxTChQm2TBOGOZhKraIbsxPrPkZgDbZIdLUZairBbk5dY7E8w79tSMI_aTGTHScY3UuLfJB6xpMLUfAkYfR9M7pENDMX1t6-M6yePUDSFS39NumCKmt8Y20ndv6Or0fpWEtbd-9EO_R7Ya00bc_5lL8nhx_nB2ld3cXV6fnd5kLldyzFAKcBaxAJv6F86wphLGOW5sUXMoeLpQ1XXeGMYaYa20kOeFqlWlXCV5w5fkaM59DcPblLrqzkeHbWt6TBV1rooSSpBCJms-W10YYgzY6NfgOxM-NDD9BVnPkHWCrL8h6zItHf7kT7bD-m_ll2oy8NkQk9Q_YdDPwxT6dPN_sZ-UL4lg</recordid><startdate>2025</startdate><enddate>2025</enddate><creator>Huang, Kai</creator><creator>Yan, Chen</creator><creator>Abdelghany, Lina</creator><creator>Zhang, Xu</creator><creator>Jingu, Keiichi</creator><creator>Li, Tao-Sheng</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2025</creationdate><title>Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition</title><author>Huang, Kai ; Yan, Chen ; Abdelghany, Lina ; Zhang, Xu ; Jingu, Keiichi ; Li, Tao-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-e841cbee51b3005ca0f74acc3ab5d31535739dd2fa00f4bb8b12259d979c783f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>A549 Cells</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer Research</topic><topic>Carcinoma, Lewis Lung - drug therapy</topic><topic>Carcinoma, Lewis Lung - pathology</topic><topic>Carcinoma, Lewis Lung - radiotherapy</topic><topic>Cardiology</topic><topic>Cell Line, Tumor</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Medical Biochemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Nude</topic><topic>Poly(ADP-ribose) Polymerase Inhibitors - pharmacology</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Radiation Tolerance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><creatorcontrib>Abdelghany, Lina</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Jingu, Keiichi</creatorcontrib><creatorcontrib>Li, Tao-Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Kai</au><au>Yan, Chen</au><au>Abdelghany, Lina</au><au>Zhang, Xu</au><au>Jingu, Keiichi</au><au>Li, Tao-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2025</date><risdate>2025</risdate><volume>480</volume><issue>1</issue><spage>341</spage><epage>353</epage><pages>341-353</pages><issn>0300-8177</issn><issn>1573-4919</issn><eissn>1573-4919</eissn><abstract>Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of nicaraven to attenuate cancer radioresistance during fractionated radiotherapy. Tumor models were established in C57BL/6 mice and BALB/c nude mice by subcutaneous injection of Lewis mouse lung carcinoma cancer cells and A549 human lung cancer cells, respectively. When the tumors had grown to approximately 100 mm
3
, we initiated fractionated radiotherapy. Nicaraven or saline was administered immediately after each irradiation exposure. Compared to saline treatment, nicaraven administration significantly induced gamma-H2AX foci formation and cell apoptosis in tumors at 1 or 3 days after an additional challenge exposure to 10 Gy and inhibited tumor growth during the short-term follow-up period, suggesting increased radiosensitivity of cancer cells. Moreover, the expression of PARP in tumor tissue was decreased by nicaraven administration. Our data suggest that nicaraven likely attenuates the acquired radioresistance of cancers through PARP inhibition.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38466467</pmid><doi>10.1007/s11010-024-04958-6</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2025, Vol.480 (1), p.341-353 |
| issn | 0300-8177 1573-4919 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2956161848 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | A549 Cells Animals Biochemistry Biomedical and Life Sciences Cancer Research Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - pathology Carcinoma, Lewis Lung - radiotherapy Cardiology Cell Line, Tumor Humans Life Sciences Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Medical Biochemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism Radiation Tolerance - drug effects |
| title | Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T19%3A56%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nicaraven%20attenuates%20the%20acquired%20radioresistance%20of%20established%20tumors%20in%20mouse%20models%20via%20PARP%20inhibition&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Huang,%20Kai&rft.date=2025&rft.volume=480&rft.issue=1&rft.spage=341&rft.epage=353&rft.pages=341-353&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-024-04958-6&rft_dat=%3Cproquest_cross%3E2956161848%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2956161848&rft_id=info:pmid/38466467&rfr_iscdi=true |