Orthotopic and metastatic tumour models in preclinical cancer research

Mouse models of disease play a pivotal role at all stages of cancer drug development. Cell-line derived subcutaneous tumour models are predominant in early drug discovery, but there is growing recognition of the importance of the more complex orthotopic and metastatic tumour models for understanding...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2024-05, Vol.257, p.108631-108631, Article 108631
Hauptverfasser:	Stribbling, Stephen M., Beach, Callum, Ryan, Anderson J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drugs Metastatic Organoids Orthotopic PDX Preclinical Syngeneic Xenograft
Online-Zugang:	Volltext
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