Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentia...
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| Veröffentlicht in: | Biochemistry (Moscow) 2024, Vol.89 (1), p.148-158 |
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| creator | Radojičić, Ognjen Pažitná, Lucia Dobrijević, Zorana Kundalia, Paras Kianičková, Kristina Katrlík, Jaroslav Marković, Vesna Mandić Miković, Željko Nedić, Olgica Robajac, Dragana |
| description | Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentiate between healthy pregnant women (
n
= 49) and women with GDM (
n
= 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%. An increase in the Gb3 antigen and α2,3-sialylation correlated positively with GDM, whereas the amount of fucosylated glycans correlated negatively with the content of terminal Gal/GlcNAc. The content of GlcNAc oligomers correlated with the highest number of blood analytes, indices, and demographic characteristics, but failed to discriminate between the groups. The presence of terminal Gal residues correlated positively with the glucose levels and negatively with the LDL levels in the non-GDM group only. The results suggest fucosylation, terminal galactosylation, and the presence of Gb3 antigen as prediction markers of GDM. |
| doi_str_mv | 10.1134/S0006297924010097 |
| format | Article |
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n
= 49) and women with GDM (
n
= 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%. An increase in the Gb3 antigen and α2,3-sialylation correlated positively with GDM, whereas the amount of fucosylated glycans correlated negatively with the content of terminal Gal/GlcNAc. The content of GlcNAc oligomers correlated with the highest number of blood analytes, indices, and demographic characteristics, but failed to discriminate between the groups. The presence of terminal Gal residues correlated positively with the glucose levels and negatively with the LDL levels in the non-GDM group only. The results suggest fucosylation, terminal galactosylation, and the presence of Gb3 antigen as prediction markers of GDM.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297924010097</identifier><identifier>PMID: 38467551</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Analysis ; Antigens ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Blood sugar ; Correlation ; Demographics ; Diabetes in pregnancy ; Diabetes mellitus ; Diabetes, Gestational - diagnosis ; Diabetes, Gestational - metabolism ; Diagnosis ; Female ; Fetuses ; Galactose ; Gestational diabetes ; Glucose ; Glucose metabolism ; Glycosylation ; Health aspects ; Health risks ; Humans ; Infant, Newborn ; Lectins ; Lectins - metabolism ; Life Sciences ; Lipid metabolism ; Lipids ; Low density lipoprotein ; Medical diagnosis ; Microbiology ; N-Acetylglucosamine ; Polysaccharides ; Pregnancy ; Pregnancy complications ; Pregnant women ; Prognosis ; Risk factors</subject><ispartof>Biochemistry (Moscow), 2024, Vol.89 (1), p.148-158</ispartof><rights>Pleiades Publishing, Ltd. 2024</rights><rights>COPYRIGHT 2024 Springer</rights><rights>Pleiades Publishing, Ltd. 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c391t-894d15a0dd73bd8c6d6d3d2e8b2bd123d0b73a1872c47711ed743fea201ca5fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297924010097$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297924010097$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38467551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radojičić, Ognjen</creatorcontrib><creatorcontrib>Pažitná, Lucia</creatorcontrib><creatorcontrib>Dobrijević, Zorana</creatorcontrib><creatorcontrib>Kundalia, Paras</creatorcontrib><creatorcontrib>Kianičková, Kristina</creatorcontrib><creatorcontrib>Katrlík, Jaroslav</creatorcontrib><creatorcontrib>Marković, Vesna Mandić</creatorcontrib><creatorcontrib>Miković, Željko</creatorcontrib><creatorcontrib>Nedić, Olgica</creatorcontrib><creatorcontrib>Robajac, Dragana</creatorcontrib><title>Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentiate between healthy pregnant women (
n
= 49) and women with GDM (
n
= 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%. An increase in the Gb3 antigen and α2,3-sialylation correlated positively with GDM, whereas the amount of fucosylated glycans correlated negatively with the content of terminal Gal/GlcNAc. The content of GlcNAc oligomers correlated with the highest number of blood analytes, indices, and demographic characteristics, but failed to discriminate between the groups. The presence of terminal Gal residues correlated positively with the glucose levels and negatively with the LDL levels in the non-GDM group only. The results suggest fucosylation, terminal galactosylation, and the presence of Gb3 antigen as prediction markers of GDM.</description><subject>Analysis</subject><subject>Antigens</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Blood sugar</subject><subject>Correlation</subject><subject>Demographics</subject><subject>Diabetes in pregnancy</subject><subject>Diabetes mellitus</subject><subject>Diabetes, Gestational - diagnosis</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fetuses</subject><subject>Galactose</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glycosylation</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lectins</subject><subject>Lectins - metabolism</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Medical diagnosis</subject><subject>Microbiology</subject><subject>N-Acetylglucosamine</subject><subject>Polysaccharides</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnant women</subject><subject>Prognosis</subject><subject>Risk factors</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFP3DAQha0KVBbaH9ALssSFS6jHTuz4iCgsSFRUgp4jx56sjJIY7OTAv6-jhaJSkA_W-H1v9KxHyDdgJwCi_H7LGJNcK81LBoxp9YmsQLK6EKxkO2S1yMWi75H9lO7zyJkWn8meqEupqgpW5O4W4zzQdf9kw4DUJGroD282Y0iTt9SMjv6K4WW8MHYKkfqRrjFNZvJhNP3Ctzhhoj-x7_00py9ktzN9wq_P9wH5fXF-d3ZZXN-sr85OrwsrNExFrUsHlWHOKdG62konnXAc65a3DrhwrFXCQK24LZUCQKdK0aHhDKypOisOyPF270MMj3NO1Aw-2RzCjBjm1HBdSai0FJDRozfofZhjTr9QXArOSiVeqY3psfFjF6Zo7LK0OVU1r5QGJjN18g6Vj8PB2zBi5_P7PwbYGmwMKUXsmofoBxOfGmDN0mTzX5PZc_gceG4HdH8dL9VlgG-BlKVxg_H1Rx9v_QMpvKUE</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Radojičić, Ognjen</creator><creator>Pažitná, Lucia</creator><creator>Dobrijević, Zorana</creator><creator>Kundalia, Paras</creator><creator>Kianičková, Kristina</creator><creator>Katrlík, Jaroslav</creator><creator>Marković, Vesna Mandić</creator><creator>Miković, Željko</creator><creator>Nedić, Olgica</creator><creator>Robajac, Dragana</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus</title><author>Radojičić, Ognjen ; Pažitná, Lucia ; Dobrijević, Zorana ; Kundalia, Paras ; Kianičková, Kristina ; Katrlík, Jaroslav ; Marković, Vesna Mandić ; Miković, Željko ; Nedić, Olgica ; Robajac, Dragana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-894d15a0dd73bd8c6d6d3d2e8b2bd123d0b73a1872c47711ed743fea201ca5fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Antigens</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Blood sugar</topic><topic>Correlation</topic><topic>Demographics</topic><topic>Diabetes in pregnancy</topic><topic>Diabetes mellitus</topic><topic>Diabetes, Gestational - diagnosis</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fetuses</topic><topic>Galactose</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glycosylation</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lectins</topic><topic>Lectins - metabolism</topic><topic>Life Sciences</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Medical diagnosis</topic><topic>Microbiology</topic><topic>N-Acetylglucosamine</topic><topic>Polysaccharides</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnant women</topic><topic>Prognosis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radojičić, Ognjen</creatorcontrib><creatorcontrib>Pažitná, Lucia</creatorcontrib><creatorcontrib>Dobrijević, Zorana</creatorcontrib><creatorcontrib>Kundalia, Paras</creatorcontrib><creatorcontrib>Kianičková, Kristina</creatorcontrib><creatorcontrib>Katrlík, Jaroslav</creatorcontrib><creatorcontrib>Marković, Vesna Mandić</creatorcontrib><creatorcontrib>Miković, Željko</creatorcontrib><creatorcontrib>Nedić, Olgica</creatorcontrib><creatorcontrib>Robajac, Dragana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radojičić, Ognjen</au><au>Pažitná, Lucia</au><au>Dobrijević, Zorana</au><au>Kundalia, Paras</au><au>Kianičková, Kristina</au><au>Katrlík, Jaroslav</au><au>Marković, Vesna Mandić</au><au>Miković, Željko</au><au>Nedić, Olgica</au><au>Robajac, Dragana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2024</date><risdate>2024</risdate><volume>89</volume><issue>1</issue><spage>148</spage><epage>158</epage><pages>148-158</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentiate between healthy pregnant women (
n
= 49) and women with GDM (
n
= 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%. An increase in the Gb3 antigen and α2,3-sialylation correlated positively with GDM, whereas the amount of fucosylated glycans correlated negatively with the content of terminal Gal/GlcNAc. The content of GlcNAc oligomers correlated with the highest number of blood analytes, indices, and demographic characteristics, but failed to discriminate between the groups. The presence of terminal Gal residues correlated positively with the glucose levels and negatively with the LDL levels in the non-GDM group only. The results suggest fucosylation, terminal galactosylation, and the presence of Gb3 antigen as prediction markers of GDM.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>38467551</pmid><doi>10.1134/S0006297924010097</doi><tpages>11</tpages></addata></record> |
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| ispartof | Biochemistry (Moscow), 2024, Vol.89 (1), p.148-158 |
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| subjects | Analysis Antigens Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Blood sugar Correlation Demographics Diabetes in pregnancy Diabetes mellitus Diabetes, Gestational - diagnosis Diabetes, Gestational - metabolism Diagnosis Female Fetuses Galactose Gestational diabetes Glucose Glucose metabolism Glycosylation Health aspects Health risks Humans Infant, Newborn Lectins Lectins - metabolism Life Sciences Lipid metabolism Lipids Low density lipoprotein Medical diagnosis Microbiology N-Acetylglucosamine Polysaccharides Pregnancy Pregnancy complications Pregnant women Prognosis Risk factors |
| title | Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus |
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