Brain‐Targeted Black Phosphorus‐Based Nanotherapeutic Platform for Enhanced Hypericin Delivery in Depression

Depression is a significant global health concern that remains inadequately treated due to the limited effectiveness of conventional drug therapies. One potential therapeutic agent, hypericin (HYP), is identified as an effective natural antidepressant. However, its poor water solubility, low bioavai...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-08, Vol.20 (31), p.e2310608-n/a
Hauptverfasser:	Tan, Hanxu, Cao, Kerun, Zhao, Yuying, Zhong, Jialong, Deng, Di, Pan, Bo, Zhang, Juping, Zhang, Rong, Wang, Zhiyu, Chen, Tongkai, Shi, Yafei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - chemistry Antidepressants Antidepressive Agents - chemistry Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use anti‐depression Bioavailability black phosphorus Blood-Brain Barrier - metabolism blood‐brain‐barrier Brain Brain - drug effects Brain - metabolism Depression - drug therapy Drug Delivery Systems Effectiveness hypericin In vivo methods and tests Mental depression Mice Nanoparticles - chemistry Oxidative Stress - drug effects Perylene - analogs & derivatives Perylene - chemistry Perylene - pharmacology Pharmacology Phosphorus Phosphorus - chemistry photothermal properties Public health
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