Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort

Objective Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies,...

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Veröffentlicht in:	Annals of neurology 2024-06, Vol.95 (6), p.1058-1068
Hauptverfasser:	Palpatzis, Eleni, Akinci, Muge, Aguilar‐Dominguez, Pablo, Garcia‐Prat, Marina, Blennow, Kaj, Zetterberg, Henrik, Carboni, Margherita, Kollmorgen, Gwendlyn, Wild, Norbert, Fauria, Karine, Falcon, Carles, Gispert, Juan Domingo, Suárez‐Calvet, Marc, Grau‐Rivera, Oriol, Sánchez‐Benavides, Gonzalo, Arenaza‐Urquijo, Eider M., Peña‐Gómez, Cleofé, Anastasi, Federica, Beteta, Annabella, Brugulat‐Serrat, Anna, Cacciaglia, Raffaele, Cumplido‐Mayoral, Irene, Cañas, Alba, Campo, Marta, Deulofeu, Carme, Cumplido, Irene, Dominguez, Ruth, Emilio, Maria, Fuentes, Sherezade, Genius, Patricia, González‐Escalante, Armand, Hernández, Laura, Huguet, Jordi, Marne, Paula, Menchón, Tania, Minguillon, Carolina, Ortiz, Paula, Pelkmans, Wiesje, Polo, Albina, Pradas, Sandra, Rodríguez‐Fernéndez, Blanca, Sadeghi, Iman, Shekari, Mahnaz, Soteras, Anna, Stankeviciute, Laura, Vilanova, Marc, Vilor‐Tejedor, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Atrophy Brain Cerebrospinal fluid Children Inflammation Interleukin 6 Magnetic resonance imaging Mental disorders Middle age Multiple regression analysis Neurodegenerative diseases Neuroimaging Pathogenesis Sex Substantia grisea
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