Design, synthesis, and biological evaluation of 3‐benzenesulfonamide‐linked 3‐hydrazinoisatin derivatives as carbonic anhydrase inhibitors

A new series of isatin‐linked benzenesulfonamide derivatives (9a–w) were synthesized using the tail approach and assayed for their inhibitory potency against four different human carbonic anhydrase (hCA) isoforms, hCA I, II, IX, and XII. Most of these synthesized compounds exhibited interesting inhi...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2024-06, Vol.357 (6), p.e2300718-n/a
Hauptverfasser:	Swain, Baijayantimala, Marde, Vaibhav S., Singh, Priti, Angeli, Andrea, Khan, Abrar, Yaddanapudi, Venkata M., Ullah, Qasim, Supuran, Claudiu T., Arifuddin, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzenesulfonamides cancer carbonic anhydrase Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Dose-Response Relationship, Drug Drug Design Humans isatin Isatin - chemical synthesis Isatin - chemistry Isatin - pharmacology Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism isoform selectivity Molecular Structure Structure-Activity Relationship sulfonamide Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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