Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor characteristics is necessary for managing chemotherapy treat...

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Veröffentlicht in:	Journal of pharmaceutical analysis 2024-02, Vol.14 (2), p.196-210
Hauptverfasser:	Olkowicz, Mariola, Ramadan, Khaled, Rosales-Solano, Hernando, Yu, Miao, Wang, Aizhou, Cypel, Marcelo, Pawliszyn, Janusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Aldosterone Antineoplastic drugs Biomarkers Cancer therapies Chemotherapy Clinical outcomes Colorectal cancer Colorectal carcinoma Disease Drug dosages Drug therapy Energy metabolism Inflammation In vivo lung chemo-perfusion Lipids Lung diseases Medical prognosis Metabolic response Metabolism Metabolites Metabolomics Metastases Metastasis Oxaliplatin Patients Perfusion Phenotypes Physiology Pulmonary metastases Respiratory function Solid phase methods Solid-phase microextraction (SPME) microprobes Spatial metabolomics Toxicity
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