Autism spectrum disorder detection with kNN imputer and machine learning classifiers via questionnaire mode of screening

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. ASD cannot be fully cured, but early-stage diagnosis followed by therapies and rehabilitation helps an autistic person to live a quality life. Clinical diagnosis of ASD symptoms via questionnaire and screening tests such as Autism Spectrum Quotient-10 (AQ-10) and Quantitative Check-list for Autism in Toddlers (Q-chat) are expensive, inaccessible, and time-consuming processes. Machine learning (ML) techniques are beneficial to predict ASD easily at the initial stage of diagnosis. The main aim of this work is to classify ASD and typical developed (TD) class data using ML classifiers. In our work, we have used different ASD data sets of all age groups (toddlers, adults, children, and adolescents) to classify ASD and TD cases. We implemented One-Hot encoding to translate categorical data into numerical data during preprocessing. We then used kNN Imputer with MinMaxScaler feature transformation to handle missing values and data normalization. ASD and TD class data is classified using Support vector machine, k-nearest-neighbor (KNN), random forest (RF), and artificial neural network classifiers. RF gives the best performance in terms of the accuracy of 100% with different training and testing data split for all four types of data sets and has no over-fitting issue. We have also examined our results with already published work, including recent methods like Deep Neural Network (DNN) and Convolution Neural Network (CNN). Even using complex architectures like DNN and CNN, our proposed methods provide the best results with low-complexity models. In contrast, existing methods have shown accuracy upto 98% with log-loss upto 15%. Our proposed methodology demonstrates the improved generalization for real-time ASD detection during clinical trials.