Neuropeptide W protects against ovarian oxidative injury and reinforces ovarian steroidogenic activity via the upregulation of ERα expression

The aim of this study was to investigate the protective effect of neuropeptide W (NPW) on ovarian ischemia-reperfusion-induced oxidative injury and ovarian steroid metabolism. Rats were randomly divided into control and ischemia groups that received either saline or NPW (0.1 or 5 μg/kg/day). Bilater...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2024-06, Vol.76 (6), p.606-615
Hauptverfasser:	Arabacı Tamer, Sevil, Şen, Leyla Semiha, Güneş, Kasım, Yüksel, Meral, Çetinel, Şule, Yeğen, Berrak Ç
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase - metabolism Estrogen Receptor alpha - metabolism Female Lipid Peroxidation - drug effects Neuropeptides - metabolism Ovary - drug effects Ovary - metabolism Oxidative Stress - drug effects Protective Agents - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction - drug effects Up-Regulation - drug effects Uterus - drug effects Uterus - metabolism
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