Mathematical Modeling of PI3K/Akt Pathway in Microglia

The motility of microglia involves intracellular signaling pathways that are predominantly controlled by changes in cytosolic Ca2+ and activation of PI3K/Akt (phosphoinositide-3-kinase/protein kinase B). In this letter, we develop a novel biophysical model for cytosolic Ca2+ activation of the PI3K/A...

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Veröffentlicht in:	Neural computation 2024-03, Vol.36 (4), p.645-676
Hauptverfasser:	Poshtkohi, Alireza, Wade, John, McDaid, Liam, Liu, Junxiu, Dallas, Mark L, Bithell, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Calcium - metabolism Calcium ions Kinases Microglia - metabolism Optimization techniques Parameter estimation Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptors Receptors, Purinergic - metabolism Transient response
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