Qi‐dan‐dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway

Context Qi‐dan‐dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. Objective This study reveals the mechanism by which QDD ameliorates DKD. Materials and Methods The compounds in QDD were identified by high‐performance li...

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Veröffentlicht in:	Environmental toxicology 2024-06, Vol.39 (6), p.3481-3499
Hauptverfasser:	Kuang, Liuyan, You, Yanting, Qi, Jieying, Chen, Jieyu, Zhou, Xinghong, Ji, Shuai, Cheng, Jingru, Kwan, Hiu Yee, Jiang, Pingping, Sun, Xiaomin, Su, Mengting, Wang, Ming, Chen, Wenxiao, Luo, Ren, Zhao, Xiaoshan, Zhou, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Bioinformatics Cell Line Cell migration Chromatography Creatinine Damage detection Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy diabetic kidney disease Diabetic Nephropathies - drug therapy Diabetic Nephropathies - pathology Drugs, Chinese Herbal - pharmacology epithelial‐mesenchymal transition Fibrosis Genes High performance liquid chromatography HPLC Humans Inflammation Inflammatory response Kidney - drug effects Kidney - pathology Kidney diseases Kidneys Kinases Liquid chromatography Male MAP kinase Mass spectrometry Mass spectroscopy Mice network pharmacology p38 Mitogen-Activated Protein Kinases - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Qi‐dan‐dihuang decoction Quadrupoles Rapamycin Rats Rats, Sprague-Dawley renal fibrosis Signal transduction Signal Transduction - drug effects TOR protein TOR Serine-Threonine Kinases - metabolism Urea
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