Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial
Cubital tunnel syndrome (CBTS) impairs hand function, with limited conservative options often leading to surgery. Chitosan neuroregenerative effects delivered via phonophoresis provide a rationale for testing this emerging treatment approach. The primary goal of this research was to assess the impac...
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| Veröffentlicht in: | Journal of hand therapy 2024-10, Vol.37 (4), p.653-661 |
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| creator | ElGendy, Mohamed H. Fetoh, Sarah A. Salem, Shaimaa E. Daihom, Baher A. Fahmy, Ebtesam M. ElMeligie, Mohamed M. |
| description | Cubital tunnel syndrome (CBTS) impairs hand function, with limited conservative options often leading to surgery. Chitosan neuroregenerative effects delivered via phonophoresis provide a rationale for testing this emerging treatment approach.
The primary goal of this research was to assess the impact of chitosan phonophoresis on the conductivity of the ulnar nerve, as well as its effects on pain levels and functional outcomes in individuals diagnosed with mild to moderate CBTS.
Double-blind randomized controlled trial.
This was a prospective, double-blinded, randomized controlled study. The participants consisted of 54 individuals aged between 20–35 years who were randomly assigned using block randomization. The control group (n = 27) received standard hand therapy alone, while the experimental group (n = 27) received both standard hand therapy and chitosan phonophoresis. Both groups underwent three treatment sessions per week, each lasting for 60–72 minutes, over a period of five weeks. Pre- and post-intervention evaluations included assessments of ulnar nerve conduction velocity (NCV), pain assessment using the numerical pain rating scale (NPRS), as well as hand function evaluated using the Quick Disabilities of Arm Shoulder Hand (QuickDASH) questionnaire.
After the intervention, the experimental group significantly improved in all outcome measures compared to the control group. Accordingly, ulnar NCV (MD = 2.233 m/sec; CI = 1.63:2.83; p |
| doi_str_mv | 10.1016/j.jht.2024.02.006 |
| format | Article |
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The primary goal of this research was to assess the impact of chitosan phonophoresis on the conductivity of the ulnar nerve, as well as its effects on pain levels and functional outcomes in individuals diagnosed with mild to moderate CBTS.
Double-blind randomized controlled trial.
This was a prospective, double-blinded, randomized controlled study. The participants consisted of 54 individuals aged between 20–35 years who were randomly assigned using block randomization. The control group (n = 27) received standard hand therapy alone, while the experimental group (n = 27) received both standard hand therapy and chitosan phonophoresis. Both groups underwent three treatment sessions per week, each lasting for 60–72 minutes, over a period of five weeks. Pre- and post-intervention evaluations included assessments of ulnar nerve conduction velocity (NCV), pain assessment using the numerical pain rating scale (NPRS), as well as hand function evaluated using the Quick Disabilities of Arm Shoulder Hand (QuickDASH) questionnaire.
After the intervention, the experimental group significantly improved in all outcome measures compared to the control group. Accordingly, ulnar NCV (MD = 2.233 m/sec; CI = 1.63:2.83; p < 0.001; η2p = 0.516), NPRS (MD = −1.11; CI = −1.71: −0.50; p < 0.001; η2p = 0.208) and QuickDASH (MD = −2.72; CI = −4.54:0.87; p < 0.007; η2p = 0.133).
The study findings suggest that chitosan phonophoresis may have the potential as a supplementary treatment to hand therapy for individuals with mild to moderate CBTS. This approach demonstrated significant improvements in nerve conduction, pain reduction, and enhancement of hand function.
•Chitosan phonophoresis is a novel treatment approach for cubital tunnel syndrome.•Cubital tunnel syndrome impairs hand function, with limited effective conservative options.•Chitosan phonophoresis improved ulnar nerve conduction velocity versus standard care.•Chitosan phonophoresis provided greater pain relief compared to physical therapy alone.•Chitosan's neuroprotective effects make it well-suited for nerve compression disorders.</description><identifier>ISSN: 0894-1130</identifier><identifier>ISSN: 1545-004X</identifier><identifier>EISSN: 1545-004X</identifier><identifier>DOI: 10.1016/j.jht.2024.02.006</identifier><identifier>PMID: 38453574</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Arm ; Arthritis ; Atrophy ; Carpal tunnel syndrome ; Chitosan ; Chitosan - administration & dosage ; Clinical trials ; Conduction ; Cubital tunnel syndrome ; Cubital Tunnel Syndrome - physiopathology ; Cubital Tunnel Syndrome - therapy ; Double-Blind Method ; Elbow ; Evaluation ; Exercise ; Female ; Hand ; Humans ; Male ; Nanoparticles ; Nerve conduction ; Nerve entrapment syndrome ; Nerves ; Neural Conduction ; Pain ; Pain Management - methods ; Pain Measurement ; Phonophoresis ; Physical therapy ; Prospective Studies ; Randomization ; Randomized controlled trial ; Therapy ; Treatment Outcome ; Ulnar Nerve ; Ultrasonic imaging ; Velocity ; Wound healing ; Young Adult</subject><ispartof>Journal of hand therapy, 2024-10, Vol.37 (4), p.653-661</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><rights>2024. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c333t-68d94b149c1912c1f85cbea4633a5a4b6f60da4ffc6fe1bd7442153dc4c25ce93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3141521457?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38453574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ElGendy, Mohamed H.</creatorcontrib><creatorcontrib>Fetoh, Sarah A.</creatorcontrib><creatorcontrib>Salem, Shaimaa E.</creatorcontrib><creatorcontrib>Daihom, Baher A.</creatorcontrib><creatorcontrib>Fahmy, Ebtesam M.</creatorcontrib><creatorcontrib>ElMeligie, Mohamed M.</creatorcontrib><title>Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial</title><title>Journal of hand therapy</title><addtitle>J Hand Ther</addtitle><description>Cubital tunnel syndrome (CBTS) impairs hand function, with limited conservative options often leading to surgery. Chitosan neuroregenerative effects delivered via phonophoresis provide a rationale for testing this emerging treatment approach.
The primary goal of this research was to assess the impact of chitosan phonophoresis on the conductivity of the ulnar nerve, as well as its effects on pain levels and functional outcomes in individuals diagnosed with mild to moderate CBTS.
Double-blind randomized controlled trial.
This was a prospective, double-blinded, randomized controlled study. The participants consisted of 54 individuals aged between 20–35 years who were randomly assigned using block randomization. The control group (n = 27) received standard hand therapy alone, while the experimental group (n = 27) received both standard hand therapy and chitosan phonophoresis. Both groups underwent three treatment sessions per week, each lasting for 60–72 minutes, over a period of five weeks. Pre- and post-intervention evaluations included assessments of ulnar nerve conduction velocity (NCV), pain assessment using the numerical pain rating scale (NPRS), as well as hand function evaluated using the Quick Disabilities of Arm Shoulder Hand (QuickDASH) questionnaire.
After the intervention, the experimental group significantly improved in all outcome measures compared to the control group. Accordingly, ulnar NCV (MD = 2.233 m/sec; CI = 1.63:2.83; p < 0.001; η2p = 0.516), NPRS (MD = −1.11; CI = −1.71: −0.50; p < 0.001; η2p = 0.208) and QuickDASH (MD = −2.72; CI = −4.54:0.87; p < 0.007; η2p = 0.133).
The study findings suggest that chitosan phonophoresis may have the potential as a supplementary treatment to hand therapy for individuals with mild to moderate CBTS. This approach demonstrated significant improvements in nerve conduction, pain reduction, and enhancement of hand function.
•Chitosan phonophoresis is a novel treatment approach for cubital tunnel syndrome.•Cubital tunnel syndrome impairs hand function, with limited effective conservative options.•Chitosan phonophoresis improved ulnar nerve conduction velocity versus standard care.•Chitosan phonophoresis provided greater pain relief compared to physical therapy alone.•Chitosan's neuroprotective effects make it well-suited for nerve compression disorders.</description><subject>Adult</subject><subject>Arm</subject><subject>Arthritis</subject><subject>Atrophy</subject><subject>Carpal tunnel syndrome</subject><subject>Chitosan</subject><subject>Chitosan - administration & dosage</subject><subject>Clinical trials</subject><subject>Conduction</subject><subject>Cubital tunnel syndrome</subject><subject>Cubital Tunnel Syndrome - physiopathology</subject><subject>Cubital Tunnel Syndrome - therapy</subject><subject>Double-Blind Method</subject><subject>Elbow</subject><subject>Evaluation</subject><subject>Exercise</subject><subject>Female</subject><subject>Hand</subject><subject>Humans</subject><subject>Male</subject><subject>Nanoparticles</subject><subject>Nerve conduction</subject><subject>Nerve entrapment syndrome</subject><subject>Nerves</subject><subject>Neural Conduction</subject><subject>Pain</subject><subject>Pain Management - methods</subject><subject>Pain Measurement</subject><subject>Phonophoresis</subject><subject>Physical therapy</subject><subject>Prospective Studies</subject><subject>Randomization</subject><subject>Randomized controlled trial</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><subject>Ulnar Nerve</subject><subject>Ultrasonic imaging</subject><subject>Velocity</subject><subject>Wound healing</subject><subject>Young Adult</subject><issn>0894-1130</issn><issn>1545-004X</issn><issn>1545-004X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc2OFCEYRStG47SjD-DGkLhxMVVCAVVdzmoyGX-SSdxo4o5Q8JGmQkHLTyftG_pW0vbowoUbIHDuDflO07wkuCOYDG-Xbtnlrsc963DfYTw8ajaEM95izL49bjZ4O7GWEIovmmcpLRgT3uPxaXNBt4xTPrJN8_POGFDZHsBDSigYpHY2hyQ92u-CD3WJkGx98ag4LyPyEA-AVPC61Fy9PoALyubjFdpL61EEZ8FcIek1MsX_ZqRDoWQVVkjIhIhW6zTKAa1BQ5S51pXZ5krl4j04lI5ex0q_QzdIhzI7aGdna2GsrWG1P0CffpBjcK4ec7TSPW-eGOkSvHjYL5uv7---3H5s7z9_-HR7c98qSmluh62e2EzYpMhEekXMlqsZJBsolVyyeTAD1pIZowYDZNYjYz3hVCumeq5gopfNm3PvPobvBVIWq00KnJMeQkminzgbRzbSsaKv_0GXUGKdRhKUsCqDMH6iyJlSMaQUwYh9tKuMR0GwOHkWi6iexcmzwL2onmvm1UNzmVfQfxN_xFbg-gxAHcXBQhRJWfAKtI3Vt9DB_qf-F3ccvjw</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>ElGendy, Mohamed H.</creator><creator>Fetoh, Sarah A.</creator><creator>Salem, Shaimaa E.</creator><creator>Daihom, Baher A.</creator><creator>Fahmy, Ebtesam M.</creator><creator>ElMeligie, Mohamed M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20241001</creationdate><title>Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial</title><author>ElGendy, Mohamed H. ; Fetoh, Sarah A. ; Salem, Shaimaa E. ; Daihom, Baher A. ; Fahmy, Ebtesam M. ; ElMeligie, Mohamed M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-68d94b149c1912c1f85cbea4633a5a4b6f60da4ffc6fe1bd7442153dc4c25ce93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Arm</topic><topic>Arthritis</topic><topic>Atrophy</topic><topic>Carpal tunnel syndrome</topic><topic>Chitosan</topic><topic>Chitosan - administration & dosage</topic><topic>Clinical trials</topic><topic>Conduction</topic><topic>Cubital tunnel syndrome</topic><topic>Cubital Tunnel Syndrome - physiopathology</topic><topic>Cubital Tunnel Syndrome - therapy</topic><topic>Double-Blind Method</topic><topic>Elbow</topic><topic>Evaluation</topic><topic>Exercise</topic><topic>Female</topic><topic>Hand</topic><topic>Humans</topic><topic>Male</topic><topic>Nanoparticles</topic><topic>Nerve conduction</topic><topic>Nerve entrapment syndrome</topic><topic>Nerves</topic><topic>Neural Conduction</topic><topic>Pain</topic><topic>Pain Management - methods</topic><topic>Pain Measurement</topic><topic>Phonophoresis</topic><topic>Physical therapy</topic><topic>Prospective Studies</topic><topic>Randomization</topic><topic>Randomized controlled trial</topic><topic>Therapy</topic><topic>Treatment Outcome</topic><topic>Ulnar Nerve</topic><topic>Ultrasonic imaging</topic><topic>Velocity</topic><topic>Wound healing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ElGendy, Mohamed H.</creatorcontrib><creatorcontrib>Fetoh, Sarah A.</creatorcontrib><creatorcontrib>Salem, Shaimaa E.</creatorcontrib><creatorcontrib>Daihom, Baher A.</creatorcontrib><creatorcontrib>Fahmy, Ebtesam M.</creatorcontrib><creatorcontrib>ElMeligie, Mohamed M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hand therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ElGendy, Mohamed H.</au><au>Fetoh, Sarah A.</au><au>Salem, Shaimaa E.</au><au>Daihom, Baher A.</au><au>Fahmy, Ebtesam M.</au><au>ElMeligie, Mohamed M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial</atitle><jtitle>Journal of hand therapy</jtitle><addtitle>J Hand Ther</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>37</volume><issue>4</issue><spage>653</spage><epage>661</epage><pages>653-661</pages><issn>0894-1130</issn><issn>1545-004X</issn><eissn>1545-004X</eissn><abstract>Cubital tunnel syndrome (CBTS) impairs hand function, with limited conservative options often leading to surgery. Chitosan neuroregenerative effects delivered via phonophoresis provide a rationale for testing this emerging treatment approach.
The primary goal of this research was to assess the impact of chitosan phonophoresis on the conductivity of the ulnar nerve, as well as its effects on pain levels and functional outcomes in individuals diagnosed with mild to moderate CBTS.
Double-blind randomized controlled trial.
This was a prospective, double-blinded, randomized controlled study. The participants consisted of 54 individuals aged between 20–35 years who were randomly assigned using block randomization. The control group (n = 27) received standard hand therapy alone, while the experimental group (n = 27) received both standard hand therapy and chitosan phonophoresis. Both groups underwent three treatment sessions per week, each lasting for 60–72 minutes, over a period of five weeks. Pre- and post-intervention evaluations included assessments of ulnar nerve conduction velocity (NCV), pain assessment using the numerical pain rating scale (NPRS), as well as hand function evaluated using the Quick Disabilities of Arm Shoulder Hand (QuickDASH) questionnaire.
After the intervention, the experimental group significantly improved in all outcome measures compared to the control group. Accordingly, ulnar NCV (MD = 2.233 m/sec; CI = 1.63:2.83; p < 0.001; η2p = 0.516), NPRS (MD = −1.11; CI = −1.71: −0.50; p < 0.001; η2p = 0.208) and QuickDASH (MD = −2.72; CI = −4.54:0.87; p < 0.007; η2p = 0.133).
The study findings suggest that chitosan phonophoresis may have the potential as a supplementary treatment to hand therapy for individuals with mild to moderate CBTS. This approach demonstrated significant improvements in nerve conduction, pain reduction, and enhancement of hand function.
•Chitosan phonophoresis is a novel treatment approach for cubital tunnel syndrome.•Cubital tunnel syndrome impairs hand function, with limited effective conservative options.•Chitosan phonophoresis improved ulnar nerve conduction velocity versus standard care.•Chitosan phonophoresis provided greater pain relief compared to physical therapy alone.•Chitosan's neuroprotective effects make it well-suited for nerve compression disorders.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38453574</pmid><doi>10.1016/j.jht.2024.02.006</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of hand therapy, 2024-10, Vol.37 (4), p.653-661 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adult Arm Arthritis Atrophy Carpal tunnel syndrome Chitosan Chitosan - administration & dosage Clinical trials Conduction Cubital tunnel syndrome Cubital Tunnel Syndrome - physiopathology Cubital Tunnel Syndrome - therapy Double-Blind Method Elbow Evaluation Exercise Female Hand Humans Male Nanoparticles Nerve conduction Nerve entrapment syndrome Nerves Neural Conduction Pain Pain Management - methods Pain Measurement Phonophoresis Physical therapy Prospective Studies Randomization Randomized controlled trial Therapy Treatment Outcome Ulnar Nerve Ultrasonic imaging Velocity Wound healing Young Adult |
| title | Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial |
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