LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways

Excessive inflammatory response and increased oxidative stress play an essential role in the pathophysiology of ischemia/reperfusion (I/R)-induced acute kidney injury (IRI-AKI). Emerging evidence suggests that lipoxin A4 (LXA4), as an endogenous negative regulator in inflammation, can ameliorate sev...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2024-04, Vol.261, p.110167-110167, Article 110167
Hauptverfasser:	Tie, Hongtao, Kuang, Ge, Gong, Xia, Zhang, Lidan, Zhao, Zizuo, Wu, Shengwang, Huang, Wenya, Chen, Xiahong, Yuan, Yinglin, Li, Zhenhan, Li, Hongzhong, Zhang, Li, Wan, Jingyuan, Wang, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - prevention & control Animals Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Interleukin-1 Receptor-Associated Kinases - pharmacology IRAK-M IRG1 Ischemia/reperfusion Kidney - metabolism Lipoxin A4 Lipoxins Mice NF-E2-Related Factor 2 - metabolism Nrf2 Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction Succinates TNF Receptor-Associated Factor 6 - metabolism TNF Receptor-Associated Factor 6 - pharmacology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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