Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology
Phytochemical studies on 95 % ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The...
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| Veröffentlicht in: | Chemistry & biodiversity 2024-05, Vol.21 (5), p.e202302111-n/a |
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| creator | Zhao, Jin‐Na Yu, Shu‐Fei Wu, Zhi‐Hang Chen, Lu Fu, Rong Li, Ze Qu, Yan‐Liang Huang, Jian Wang, Li‐Bo Piao, Xian‐Mei Wang, Jin‐Hui |
| description | Phytochemical studies on 95 % ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The anti‐inflammatory activity of amide compounds 1–4 and 6–9 by investigating their impact on the release of nitric oxide (NO) in MH−S cells. Our findings unveiled significant inhibitory effects on NO secretion. Compound 1 exhibited robust dose‐dependent suppression, with pronounced inhibition observed at both 20 μM (P |
| doi_str_mv | 10.1002/cbdv.202302111 |
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And Their Anti‐Inflammatory Activities Combined Network Pharmacology</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhao, Jin‐Na ; Yu, Shu‐Fei ; Wu, Zhi‐Hang ; Chen, Lu ; Fu, Rong ; Li, Ze ; Qu, Yan‐Liang ; Huang, Jian ; Wang, Li‐Bo ; Piao, Xian‐Mei ; Wang, Jin‐Hui</creator><creatorcontrib>Zhao, Jin‐Na ; Yu, Shu‐Fei ; Wu, Zhi‐Hang ; Chen, Lu ; Fu, Rong ; Li, Ze ; Qu, Yan‐Liang ; Huang, Jian ; Wang, Li‐Bo ; Piao, Xian‐Mei ; Wang, Jin‐Hui</creatorcontrib><description>Phytochemical studies on 95 % ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The anti‐inflammatory activity of amide compounds 1–4 and 6–9 by investigating their impact on the release of nitric oxide (NO) in MH−S cells. Our findings unveiled significant inhibitory effects on NO secretion. Compound 1 exhibited robust dose‐dependent suppression, with pronounced inhibition observed at both 20 μM (P<0.01) and 40 μM (P<0.01). Furthermore, compound 9 demonstrated noteworthy inhibitory effects at 40 μM (P<0.01). Similarly, compounds 3 and 4 displayed substantial inhibition of NO secretion at the same concentration, although the significance level was slightly lower (P<0.05). It is expected that there is a substantial association between the anti‐inflammatory activities of amides and their targets, specifically PTGS2, by combining network pharmacology and molecular docking techniques. This discovery emphasizes amides′ potential as an interesting subject for additional study in the realm of anti‐inflammatory medications.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202302111</identifier><identifier>PMID: 38453650</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Amide compounds ; Amides ; Anti-inflammation ; Anti-inflammatory agents ; Ethanol ; Inflammation ; Molecular docking ; Network pharmacology ; Nitric oxide ; Pharmacology ; Phenylpropanoids ; Secretion ; Solanum ; Solanum verbascifolium L ; Spectral analysis ; Spectrometry ; Spectrum analysis</subject><ispartof>Chemistry & biodiversity, 2024-05, Vol.21 (5), p.e202302111-n/a</ispartof><rights>2024 Wiley-VHCA AG, Zurich, Switzerland</rights><rights>2024 Wiley‐VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3281-1d7d84a6236f82b132052193d19e46594fc1fb3820ac9f10a196241c4b113923</cites><orcidid>0000-0003-3456-0148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202302111$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202302111$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38453650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Jin‐Na</creatorcontrib><creatorcontrib>Yu, Shu‐Fei</creatorcontrib><creatorcontrib>Wu, Zhi‐Hang</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Fu, Rong</creatorcontrib><creatorcontrib>Li, Ze</creatorcontrib><creatorcontrib>Qu, Yan‐Liang</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Wang, Li‐Bo</creatorcontrib><creatorcontrib>Piao, Xian‐Mei</creatorcontrib><creatorcontrib>Wang, Jin‐Hui</creatorcontrib><title>Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Phytochemical studies on 95 % ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The anti‐inflammatory activity of amide compounds 1–4 and 6–9 by investigating their impact on the release of nitric oxide (NO) in MH−S cells. Our findings unveiled significant inhibitory effects on NO secretion. Compound 1 exhibited robust dose‐dependent suppression, with pronounced inhibition observed at both 20 μM (P<0.01) and 40 μM (P<0.01). Furthermore, compound 9 demonstrated noteworthy inhibitory effects at 40 μM (P<0.01). Similarly, compounds 3 and 4 displayed substantial inhibition of NO secretion at the same concentration, although the significance level was slightly lower (P<0.05). It is expected that there is a substantial association between the anti‐inflammatory activities of amides and their targets, specifically PTGS2, by combining network pharmacology and molecular docking techniques. This discovery emphasizes amides′ potential as an interesting subject for additional study in the realm of anti‐inflammatory medications.</description><subject>Amide compounds</subject><subject>Amides</subject><subject>Anti-inflammation</subject><subject>Anti-inflammatory agents</subject><subject>Ethanol</subject><subject>Inflammation</subject><subject>Molecular docking</subject><subject>Network pharmacology</subject><subject>Nitric oxide</subject><subject>Pharmacology</subject><subject>Phenylpropanoids</subject><subject>Secretion</subject><subject>Solanum</subject><subject>Solanum verbascifolium L</subject><subject>Spectral analysis</subject><subject>Spectrometry</subject><subject>Spectrum analysis</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc-OFCEQh4nRuOvq1aMh8eJlRgroPxzHXnU3maiJk70SmgaHtWlWoHczNx_Ag8_ok8hk1jHx4omCfPUVlR9Cz4EsgRD6WvfD7ZISyggFgAfoFGqgC2hb8vBYN_QEPUnpuvDlvX2MTljLK1ZX5BT96LbGO61G3IUpZZdnM-WEbQwe563BF0bFfBfCgIPFn8OoptnjKxN7lbSzYXTlul7i1TTgzda4WKrsfn3_eTnZUXmvcog7vNLZ3brsTCpTfO8mM-APpmjjV_xpq6JXOozhy-4pemTVmMyz-_MMbd693XQXi_XH95fdar3QjLawgKEZWq5qymrb0h4YJRUFwQYQhteV4FaD7VlLidLCAlEgaspB8x6ACcrO0KuD9iaGb7NJWXqXtBnLcibMSVJR8abhVQMFffkPeh3mOJXPSUYqLirW1HtqeaB0DClFY-VNdF7FnQQi9zHJfUzyGFNpeHGvnXtvhiP-J5cCiANw50az-49Odm_Or_7KfwNopJ-u</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Zhao, Jin‐Na</creator><creator>Yu, Shu‐Fei</creator><creator>Wu, Zhi‐Hang</creator><creator>Chen, Lu</creator><creator>Fu, Rong</creator><creator>Li, Ze</creator><creator>Qu, Yan‐Liang</creator><creator>Huang, Jian</creator><creator>Wang, Li‐Bo</creator><creator>Piao, Xian‐Mei</creator><creator>Wang, Jin‐Hui</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3456-0148</orcidid></search><sort><creationdate>202405</creationdate><title>Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology</title><author>Zhao, Jin‐Na ; Yu, Shu‐Fei ; Wu, Zhi‐Hang ; Chen, Lu ; Fu, Rong ; Li, Ze ; Qu, Yan‐Liang ; Huang, Jian ; Wang, Li‐Bo ; Piao, Xian‐Mei ; Wang, Jin‐Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3281-1d7d84a6236f82b132052193d19e46594fc1fb3820ac9f10a196241c4b113923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amide compounds</topic><topic>Amides</topic><topic>Anti-inflammation</topic><topic>Anti-inflammatory agents</topic><topic>Ethanol</topic><topic>Inflammation</topic><topic>Molecular docking</topic><topic>Network pharmacology</topic><topic>Nitric oxide</topic><topic>Pharmacology</topic><topic>Phenylpropanoids</topic><topic>Secretion</topic><topic>Solanum</topic><topic>Solanum verbascifolium L</topic><topic>Spectral analysis</topic><topic>Spectrometry</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jin‐Na</creatorcontrib><creatorcontrib>Yu, Shu‐Fei</creatorcontrib><creatorcontrib>Wu, Zhi‐Hang</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Fu, Rong</creatorcontrib><creatorcontrib>Li, Ze</creatorcontrib><creatorcontrib>Qu, Yan‐Liang</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Wang, Li‐Bo</creatorcontrib><creatorcontrib>Piao, Xian‐Mei</creatorcontrib><creatorcontrib>Wang, Jin‐Hui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jin‐Na</au><au>Yu, Shu‐Fei</au><au>Wu, Zhi‐Hang</au><au>Chen, Lu</au><au>Fu, Rong</au><au>Li, Ze</au><au>Qu, Yan‐Liang</au><au>Huang, Jian</au><au>Wang, Li‐Bo</au><au>Piao, Xian‐Mei</au><au>Wang, Jin‐Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Constituents from the Heartwood of Solanum Verbascifolium L. 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Compound 1 exhibited robust dose‐dependent suppression, with pronounced inhibition observed at both 20 μM (P<0.01) and 40 μM (P<0.01). Furthermore, compound 9 demonstrated noteworthy inhibitory effects at 40 μM (P<0.01). Similarly, compounds 3 and 4 displayed substantial inhibition of NO secretion at the same concentration, although the significance level was slightly lower (P<0.05). It is expected that there is a substantial association between the anti‐inflammatory activities of amides and their targets, specifically PTGS2, by combining network pharmacology and molecular docking techniques. This discovery emphasizes amides′ potential as an interesting subject for additional study in the realm of anti‐inflammatory medications.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38453650</pmid><doi>10.1002/cbdv.202302111</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3456-0148</orcidid></addata></record> |
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| subjects | Amide compounds Amides Anti-inflammation Anti-inflammatory agents Ethanol Inflammation Molecular docking Network pharmacology Nitric oxide Pharmacology Phenylpropanoids Secretion Solanum Solanum verbascifolium L Spectral analysis Spectrometry Spectrum analysis |
| title | Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology |
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