NMR study of the structure and dynamics of the BRCT domain from the kinetochore protein KKT4

KKT4 is a multi-domain kinetochore protein specific to kinetoplastids, such as Trypanosoma brucei . It lacks significant sequence similarity to known kinetochore proteins in other eukaryotes. Our recent X-ray structure of the C-terminal region of KKT4 shows that it has a tandem BRCT (BRCA1 C Terminu...

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Veröffentlicht in:	Biomolecular NMR assignments 2024-06, Vol.18 (1), p.15-25
Hauptverfasser:	Ludzia, Patryk, Hayashi, Hanako, Robinson, Timothy, Akiyoshi, Bungo, Redfield, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemistry Biological and Medical Physics Biophysics BRCA1 protein C-Terminus Drug development Kinetochores - chemistry Kinetochores - metabolism Nuclear Magnetic Resonance, Biomolecular Physics Physics and Astronomy Polymer Sciences Protein Domains Protein structure Protein Structure, Secondary Protozoan Proteins - chemistry Protozoan Proteins - metabolism Secondary structure Trypanosoma brucei brucei
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