Understanding the complex formation of falstatin; an endogenous macromolecular inhibitor of falcipains

Proteolytic activity constitutes a fundamental process essential for the survival of the malaria parasite and is thus highly regulated. Falstatin, a protease inhibitor of Plasmodium falciparum, tightly regulates the activity of cysteine hemoglobinases, falcipain-2 and 3 (FP2, FP3), by inhibiting FP2...

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Veröffentlicht in:	International journal of biological macromolecules 2024-04, Vol.265 (Pt 1), p.130420-130420, Article 130420
Hauptverfasser:	Pasupureddy, Rahul, Verma, Sonia, Goyal, Bharti, Pant, Akansha, Sharma, Ruby, Bhatt, Shruti, Vashisht, Kapil, Singh, Shailja, Saxena, Ajay K., Dixit, Rajnikant, Chakraborti, Soumyananda, Pandey, Kailash C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Decameric model Falstatin oligomerization FP2-falstatin interaction Heat shock protein 70 Macromolecular inhibitor Protease-inhibitor multimer complex
Online-Zugang:	Volltext
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