Physical exercise: a polypill against chronic kidney disease
ABSTRACT We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise interventi...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2024-08, Vol.39 (9), p.1384-1391 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Valenzuela, Pedro L Castillo-García, Adrián Saco-Ledo, Gonzalo Santos-Lozano, Alejandro Lucia, Alejandro |
| description | ABSTRACT
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients’ physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management. |
| doi_str_mv | 10.1093/ndt/gfae062 |
| format | Article |
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We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients’ physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management.</description><identifier>ISSN: 0931-0509</identifier><identifier>ISSN: 1460-2385</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfae062</identifier><identifier>PMID: 38460948</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Exercise ; Exercise Therapy - methods ; Humans ; Life Style ; Renal Insufficiency, Chronic - therapy</subject><ispartof>Nephrology, dialysis, transplantation, 2024-08, Vol.39 (9), p.1384-1391</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the ERA. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-5548c935d1b1fbbf721047abd96102a81249093a4f66ba4bc96190d01d7ba04b3</citedby><cites>FETCH-LOGICAL-c250t-5548c935d1b1fbbf721047abd96102a81249093a4f66ba4bc96190d01d7ba04b3</cites><orcidid>0000-0003-1730-3369 ; 0000-0002-2309-3583 ; 0000-0002-5565-0997</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38460948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valenzuela, Pedro L</creatorcontrib><creatorcontrib>Castillo-García, Adrián</creatorcontrib><creatorcontrib>Saco-Ledo, Gonzalo</creatorcontrib><creatorcontrib>Santos-Lozano, Alejandro</creatorcontrib><creatorcontrib>Lucia, Alejandro</creatorcontrib><title>Physical exercise: a polypill against chronic kidney disease</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>ABSTRACT
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients’ physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management.</description><subject>Exercise</subject><subject>Exercise Therapy - methods</subject><subject>Humans</subject><subject>Life Style</subject><subject>Renal Insufficiency, Chronic - therapy</subject><issn>0931-0509</issn><issn>1460-2385</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LxDAQBuAgiruunrxLTiJI3UmatI14kcUvWNCDnkO-uhvttrVpwf57I7t69DQw8_AyvAidErgiINJ5bfv5qlQOMrqHpoRlkNC04PtoGq8kAQ5igo5CeAcAQfP8EE3SIirBiim6eVmPwRtVYfflOuODu8YKt001tr6qsFopX4cem3XX1N7gD29rN2IbnQruGB2UqgruZDdn6O3-7nXxmCyfH54Wt8vEUA59wjkrjEi5JZqUWpc5JcBypa3ICFBVEMpEfFWxMsu0YtrEvQALxOZaAdPpDF1sc9uu-Rxc6OXGB-OqStWuGYKkgrM8JzzlkV5uqemaEDpXyrbzG9WNkoD8qUvGuuSurqjPdsGD3jj7Z3_7ieB8C5qh_TfpG0S2cuY</recordid><startdate>20240830</startdate><enddate>20240830</enddate><creator>Valenzuela, Pedro L</creator><creator>Castillo-García, Adrián</creator><creator>Saco-Ledo, Gonzalo</creator><creator>Santos-Lozano, Alejandro</creator><creator>Lucia, Alejandro</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1730-3369</orcidid><orcidid>https://orcid.org/0000-0002-2309-3583</orcidid><orcidid>https://orcid.org/0000-0002-5565-0997</orcidid></search><sort><creationdate>20240830</creationdate><title>Physical exercise: a polypill against chronic kidney disease</title><author>Valenzuela, Pedro L ; Castillo-García, Adrián ; Saco-Ledo, Gonzalo ; Santos-Lozano, Alejandro ; Lucia, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-5548c935d1b1fbbf721047abd96102a81249093a4f66ba4bc96190d01d7ba04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Exercise</topic><topic>Exercise Therapy - methods</topic><topic>Humans</topic><topic>Life Style</topic><topic>Renal Insufficiency, Chronic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valenzuela, Pedro L</creatorcontrib><creatorcontrib>Castillo-García, Adrián</creatorcontrib><creatorcontrib>Saco-Ledo, Gonzalo</creatorcontrib><creatorcontrib>Santos-Lozano, Alejandro</creatorcontrib><creatorcontrib>Lucia, Alejandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valenzuela, Pedro L</au><au>Castillo-García, Adrián</au><au>Saco-Ledo, Gonzalo</au><au>Santos-Lozano, Alejandro</au><au>Lucia, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical exercise: a polypill against chronic kidney disease</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2024-08-30</date><risdate>2024</risdate><volume>39</volume><issue>9</issue><spage>1384</spage><epage>1391</epage><pages>1384-1391</pages><issn>0931-0509</issn><issn>1460-2385</issn><eissn>1460-2385</eissn><abstract>ABSTRACT
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients’ physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>38460948</pmid><doi>10.1093/ndt/gfae062</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1730-3369</orcidid><orcidid>https://orcid.org/0000-0002-2309-3583</orcidid><orcidid>https://orcid.org/0000-0002-5565-0997</orcidid></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 2024-08, Vol.39 (9), p.1384-1391 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Exercise Exercise Therapy - methods Humans Life Style Renal Insufficiency, Chronic - therapy |
| title | Physical exercise: a polypill against chronic kidney disease |
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