Changes in rate-pressure product associated with pregnancy
[Display omitted] In nonpregnant individuals, the rate-pressure product, the product of heart rate and systolic blood pressure, is used as a noninvasive surrogate of myocardial O2 consumption during cardiac stress testing. Pregnancy is considered a physiological cardiovascular stress test. Evidence...
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| Veröffentlicht in: | American journal of obstetrics & gynecology MFM 2024-04, Vol.6 (4), p.101338, Article 101338 |
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| container_title | American journal of obstetrics & gynecology MFM |
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| creator | Schenone, Claudio V. Ashley Cain, M. Schenone, Aldo L. Smith, Teagen Tsalatsanis, Athanasios Louis, Judette M. Crousillat, Daniela R. |
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In nonpregnant individuals, the rate-pressure product, the product of heart rate and systolic blood pressure, is used as a noninvasive surrogate of myocardial O2 consumption during cardiac stress testing. Pregnancy is considered a physiological cardiovascular stress test. Evidence describing the impact of pregnancy on myocardial O2 demand, as assessed by the rate-pressure product, is limited.
This study aimed to describe changes in the rate-pressure product for each pregnancy trimester, during labor and delivery, and the postpartum period among low-risk pregnancies.
This was a retrospective cohort study that assessed uncomplicated pregnancies delivered vaginally at term. We collected rate-pressure product (heart rate × systolic blood pressure) values preconception, during pregnancy for each trimester (at ≤13 weeks + 6/7 days, at 14 weeks + 0/7 days through 27 weeks + 6/7 days, and at ≥28 weeks + 0/7 days), during the labor and delivery encounter (hospital admission until complete cervical dilation, complete cervical dilation until placental delivery, and after placental delivery until hospital discharge), and during the outpatient postpartum visit at 2 to 6 weeks after delivery. We calculated the percentage change at each time point from the preconception rate-pressure product (delta rate-pressure product). We used a mixed-linear model to analyze differences in the mean delta rate-pressure product over time and the influence of prepregnancy age, prepregnancy body mass index, and neuraxial anesthesia status during labor and delivery on these estimates.
Our cohort comprised 316 patients. The mean rate-pressure product increased significantly from preconception starting at the third trimester of pregnancy and during labor and delivery (P≤.05). The mean delta rate-pressure product peaked at 12% and 38% in the third trimester and during labor and delivery, respectively. Prepregnancy body mass index was inversely correlated with the mean delta rate-pressure product changes (estimate, −0.308; 95% confidence interval, −0.536 to −0.80; P=.008). In contrast, neither the prepregnancy age, nor neuraxial anesthesia status during labor had a significant influence on this parameter.
This study validates the transient but significant increase in the rate-pressure product, a clinical estimate of myocardial O2 demand, during uncomplicated pregnancies delivered vaginally at term. Pregnant individuals with lower prepregnancy body mass index experienced a sha |
| doi_str_mv | 10.1016/j.ajogmf.2024.101338 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2954768974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2589933324000648</els_id><sourcerecordid>2954768974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-f215a44cfe751b7bf5a18d872cd163b8b78b5715510ddea528a3dbf51073996a3</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobsz9A5FeetOZzyb1QpDhFwy80euQJqdbytrOpFX27-3oFK-8SjjnOXlPHoQuCV4QTLKbamGqdl2XC4opP5QYUydoSoXK05wxdvrnPkHzGCuMMSWcC5qdowlTXDBM8im6XW5Ms4aY-CYJpoN0FyDGPkCyC63rbZeYGFvrh5ZLvny3Geqwbkxj9xforDTbCPPjOUPvjw9vy-d09fr0srxfpZYR0qUlJcJwbkuQghSyKIUhyilJrSMZK1QhVSEkEYJg58AIqgxzA0WwZHmeGTZD1-O7w0YfPcRO1z5a2G5NA20fNc0Fl5nKJR9QPqI2tDEGKPUu-NqEvSZYH8TpSo_i9EGcHsUNY1fHhL6owf0O_WgagLsRgOGfnx6CjtZDY8H5ALbTrvX_J3wDmPZ_rg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2954768974</pqid></control><display><type>article</type><title>Changes in rate-pressure product associated with pregnancy</title><source>Alma/SFX Local Collection</source><creator>Schenone, Claudio V. ; Ashley Cain, M. ; Schenone, Aldo L. ; Smith, Teagen ; Tsalatsanis, Athanasios ; Louis, Judette M. ; Crousillat, Daniela R.</creator><creatorcontrib>Schenone, Claudio V. ; Ashley Cain, M. ; Schenone, Aldo L. ; Smith, Teagen ; Tsalatsanis, Athanasios ; Louis, Judette M. ; Crousillat, Daniela R.</creatorcontrib><description>[Display omitted]
In nonpregnant individuals, the rate-pressure product, the product of heart rate and systolic blood pressure, is used as a noninvasive surrogate of myocardial O2 consumption during cardiac stress testing. Pregnancy is considered a physiological cardiovascular stress test. Evidence describing the impact of pregnancy on myocardial O2 demand, as assessed by the rate-pressure product, is limited.
This study aimed to describe changes in the rate-pressure product for each pregnancy trimester, during labor and delivery, and the postpartum period among low-risk pregnancies.
This was a retrospective cohort study that assessed uncomplicated pregnancies delivered vaginally at term. We collected rate-pressure product (heart rate × systolic blood pressure) values preconception, during pregnancy for each trimester (at ≤13 weeks + 6/7 days, at 14 weeks + 0/7 days through 27 weeks + 6/7 days, and at ≥28 weeks + 0/7 days), during the labor and delivery encounter (hospital admission until complete cervical dilation, complete cervical dilation until placental delivery, and after placental delivery until hospital discharge), and during the outpatient postpartum visit at 2 to 6 weeks after delivery. We calculated the percentage change at each time point from the preconception rate-pressure product (delta rate-pressure product). We used a mixed-linear model to analyze differences in the mean delta rate-pressure product over time and the influence of prepregnancy age, prepregnancy body mass index, and neuraxial anesthesia status during labor and delivery on these estimates.
Our cohort comprised 316 patients. The mean rate-pressure product increased significantly from preconception starting at the third trimester of pregnancy and during labor and delivery (P≤.05). The mean delta rate-pressure product peaked at 12% and 38% in the third trimester and during labor and delivery, respectively. Prepregnancy body mass index was inversely correlated with the mean delta rate-pressure product changes (estimate, −0.308; 95% confidence interval, −0.536 to −0.80; P=.008). In contrast, neither the prepregnancy age, nor neuraxial anesthesia status during labor had a significant influence on this parameter.
This study validates the transient but significant increase in the rate-pressure product, a clinical estimate of myocardial O2 demand, during uncomplicated pregnancies delivered vaginally at term. Pregnant individuals with lower prepregnancy body mass index experienced a sharper increase in this parameter. Patients who receive neuraxial anesthesia during labor and delivery experience similar changes in the rate-pressure product as those who did not.</description><identifier>ISSN: 2589-9333</identifier><identifier>EISSN: 2589-9333</identifier><identifier>DOI: 10.1016/j.ajogmf.2024.101338</identifier><identifier>PMID: 38453019</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>age ; body mass index ; cardiac workload ; double product ; low-risk ; myocardial oxygen consumption ; myocardial oxygen demand ; neuraxial anesthesia ; vaginal delivery</subject><ispartof>American journal of obstetrics & gynecology MFM, 2024-04, Vol.6 (4), p.101338, Article 101338</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-f215a44cfe751b7bf5a18d872cd163b8b78b5715510ddea528a3dbf51073996a3</cites><orcidid>0000-0002-6318-9854</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38453019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schenone, Claudio V.</creatorcontrib><creatorcontrib>Ashley Cain, M.</creatorcontrib><creatorcontrib>Schenone, Aldo L.</creatorcontrib><creatorcontrib>Smith, Teagen</creatorcontrib><creatorcontrib>Tsalatsanis, Athanasios</creatorcontrib><creatorcontrib>Louis, Judette M.</creatorcontrib><creatorcontrib>Crousillat, Daniela R.</creatorcontrib><title>Changes in rate-pressure product associated with pregnancy</title><title>American journal of obstetrics & gynecology MFM</title><addtitle>Am J Obstet Gynecol MFM</addtitle><description>[Display omitted]
In nonpregnant individuals, the rate-pressure product, the product of heart rate and systolic blood pressure, is used as a noninvasive surrogate of myocardial O2 consumption during cardiac stress testing. Pregnancy is considered a physiological cardiovascular stress test. Evidence describing the impact of pregnancy on myocardial O2 demand, as assessed by the rate-pressure product, is limited.
This study aimed to describe changes in the rate-pressure product for each pregnancy trimester, during labor and delivery, and the postpartum period among low-risk pregnancies.
This was a retrospective cohort study that assessed uncomplicated pregnancies delivered vaginally at term. We collected rate-pressure product (heart rate × systolic blood pressure) values preconception, during pregnancy for each trimester (at ≤13 weeks + 6/7 days, at 14 weeks + 0/7 days through 27 weeks + 6/7 days, and at ≥28 weeks + 0/7 days), during the labor and delivery encounter (hospital admission until complete cervical dilation, complete cervical dilation until placental delivery, and after placental delivery until hospital discharge), and during the outpatient postpartum visit at 2 to 6 weeks after delivery. We calculated the percentage change at each time point from the preconception rate-pressure product (delta rate-pressure product). We used a mixed-linear model to analyze differences in the mean delta rate-pressure product over time and the influence of prepregnancy age, prepregnancy body mass index, and neuraxial anesthesia status during labor and delivery on these estimates.
Our cohort comprised 316 patients. The mean rate-pressure product increased significantly from preconception starting at the third trimester of pregnancy and during labor and delivery (P≤.05). The mean delta rate-pressure product peaked at 12% and 38% in the third trimester and during labor and delivery, respectively. Prepregnancy body mass index was inversely correlated with the mean delta rate-pressure product changes (estimate, −0.308; 95% confidence interval, −0.536 to −0.80; P=.008). In contrast, neither the prepregnancy age, nor neuraxial anesthesia status during labor had a significant influence on this parameter.
This study validates the transient but significant increase in the rate-pressure product, a clinical estimate of myocardial O2 demand, during uncomplicated pregnancies delivered vaginally at term. Pregnant individuals with lower prepregnancy body mass index experienced a sharper increase in this parameter. Patients who receive neuraxial anesthesia during labor and delivery experience similar changes in the rate-pressure product as those who did not.</description><subject>age</subject><subject>body mass index</subject><subject>cardiac workload</subject><subject>double product</subject><subject>low-risk</subject><subject>myocardial oxygen consumption</subject><subject>myocardial oxygen demand</subject><subject>neuraxial anesthesia</subject><subject>vaginal delivery</subject><issn>2589-9333</issn><issn>2589-9333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobsz9A5FeetOZzyb1QpDhFwy80euQJqdbytrOpFX27-3oFK-8SjjnOXlPHoQuCV4QTLKbamGqdl2XC4opP5QYUydoSoXK05wxdvrnPkHzGCuMMSWcC5qdowlTXDBM8im6XW5Ms4aY-CYJpoN0FyDGPkCyC63rbZeYGFvrh5ZLvny3Geqwbkxj9xforDTbCPPjOUPvjw9vy-d09fr0srxfpZYR0qUlJcJwbkuQghSyKIUhyilJrSMZK1QhVSEkEYJg58AIqgxzA0WwZHmeGTZD1-O7w0YfPcRO1z5a2G5NA20fNc0Fl5nKJR9QPqI2tDEGKPUu-NqEvSZYH8TpSo_i9EGcHsUNY1fHhL6owf0O_WgagLsRgOGfnx6CjtZDY8H5ALbTrvX_J3wDmPZ_rg</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Schenone, Claudio V.</creator><creator>Ashley Cain, M.</creator><creator>Schenone, Aldo L.</creator><creator>Smith, Teagen</creator><creator>Tsalatsanis, Athanasios</creator><creator>Louis, Judette M.</creator><creator>Crousillat, Daniela R.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6318-9854</orcidid></search><sort><creationdate>20240401</creationdate><title>Changes in rate-pressure product associated with pregnancy</title><author>Schenone, Claudio V. ; Ashley Cain, M. ; Schenone, Aldo L. ; Smith, Teagen ; Tsalatsanis, Athanasios ; Louis, Judette M. ; Crousillat, Daniela R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-f215a44cfe751b7bf5a18d872cd163b8b78b5715510ddea528a3dbf51073996a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>age</topic><topic>body mass index</topic><topic>cardiac workload</topic><topic>double product</topic><topic>low-risk</topic><topic>myocardial oxygen consumption</topic><topic>myocardial oxygen demand</topic><topic>neuraxial anesthesia</topic><topic>vaginal delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schenone, Claudio V.</creatorcontrib><creatorcontrib>Ashley Cain, M.</creatorcontrib><creatorcontrib>Schenone, Aldo L.</creatorcontrib><creatorcontrib>Smith, Teagen</creatorcontrib><creatorcontrib>Tsalatsanis, Athanasios</creatorcontrib><creatorcontrib>Louis, Judette M.</creatorcontrib><creatorcontrib>Crousillat, Daniela R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics & gynecology MFM</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schenone, Claudio V.</au><au>Ashley Cain, M.</au><au>Schenone, Aldo L.</au><au>Smith, Teagen</au><au>Tsalatsanis, Athanasios</au><au>Louis, Judette M.</au><au>Crousillat, Daniela R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in rate-pressure product associated with pregnancy</atitle><jtitle>American journal of obstetrics & gynecology MFM</jtitle><addtitle>Am J Obstet Gynecol MFM</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>6</volume><issue>4</issue><spage>101338</spage><pages>101338-</pages><artnum>101338</artnum><issn>2589-9333</issn><eissn>2589-9333</eissn><abstract>[Display omitted]
In nonpregnant individuals, the rate-pressure product, the product of heart rate and systolic blood pressure, is used as a noninvasive surrogate of myocardial O2 consumption during cardiac stress testing. Pregnancy is considered a physiological cardiovascular stress test. Evidence describing the impact of pregnancy on myocardial O2 demand, as assessed by the rate-pressure product, is limited.
This study aimed to describe changes in the rate-pressure product for each pregnancy trimester, during labor and delivery, and the postpartum period among low-risk pregnancies.
This was a retrospective cohort study that assessed uncomplicated pregnancies delivered vaginally at term. We collected rate-pressure product (heart rate × systolic blood pressure) values preconception, during pregnancy for each trimester (at ≤13 weeks + 6/7 days, at 14 weeks + 0/7 days through 27 weeks + 6/7 days, and at ≥28 weeks + 0/7 days), during the labor and delivery encounter (hospital admission until complete cervical dilation, complete cervical dilation until placental delivery, and after placental delivery until hospital discharge), and during the outpatient postpartum visit at 2 to 6 weeks after delivery. We calculated the percentage change at each time point from the preconception rate-pressure product (delta rate-pressure product). We used a mixed-linear model to analyze differences in the mean delta rate-pressure product over time and the influence of prepregnancy age, prepregnancy body mass index, and neuraxial anesthesia status during labor and delivery on these estimates.
Our cohort comprised 316 patients. The mean rate-pressure product increased significantly from preconception starting at the third trimester of pregnancy and during labor and delivery (P≤.05). The mean delta rate-pressure product peaked at 12% and 38% in the third trimester and during labor and delivery, respectively. Prepregnancy body mass index was inversely correlated with the mean delta rate-pressure product changes (estimate, −0.308; 95% confidence interval, −0.536 to −0.80; P=.008). In contrast, neither the prepregnancy age, nor neuraxial anesthesia status during labor had a significant influence on this parameter.
This study validates the transient but significant increase in the rate-pressure product, a clinical estimate of myocardial O2 demand, during uncomplicated pregnancies delivered vaginally at term. Pregnant individuals with lower prepregnancy body mass index experienced a sharper increase in this parameter. Patients who receive neuraxial anesthesia during labor and delivery experience similar changes in the rate-pressure product as those who did not.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38453019</pmid><doi>10.1016/j.ajogmf.2024.101338</doi><orcidid>https://orcid.org/0000-0002-6318-9854</orcidid></addata></record> |
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| subjects | age body mass index cardiac workload double product low-risk myocardial oxygen consumption myocardial oxygen demand neuraxial anesthesia vaginal delivery |
| title | Changes in rate-pressure product associated with pregnancy |
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