A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques
This report was to develop a novel solvent-free method for the manufacture of biodegradable capsules for a long-term drug delivery. To manufacture an antibiotic capsule, polylactide–polyglycolide copolymers were pre-mixed with vancomycin. The mixture was then injection compression molded to form a c...
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| Veröffentlicht in: | Biomaterials 2005-08, Vol.26 (22), p.4662-4669 |
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| container_title | Biomaterials |
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| creator | Liu, Shih-Jung Tsai, Ying-E Wen-Neng Ueng, Steve Chan, Err-Cheng |
| description | This report was to develop a novel solvent-free method for the manufacture of biodegradable capsules for a long-term drug delivery. To manufacture an antibiotic capsule, polylactide–polyglycolide copolymers were pre-mixed with vancomycin. The mixture was then injection compression molded to form a cylinder with a cover of 8
mm in diameter. After the addition of gentamicin sulfate into the core, an ultrasonic welder was used to seal the capsule. An elution method and an high-performance liquid chromatography assay were employed to characterize the in vitro release rates of the antibiotics over a 30-day period. It was found that biodegradable capsules released high concentration of vancomycin and gentamicin (well above the minimum inhibition concentration) in vitro for the period of time needed to treat bone infection; i.e., 2–4 weeks. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 3 to 18
mm, which is equivalent to 16.7–100% of relative activity. By adopting this novel technique, we will be able to manufacture biodegradable capsules of various medicines for long-term drug delivery. |
| doi_str_mv | 10.1016/j.biomaterials.2004.11.053 |
| format | Article |
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mm in diameter. After the addition of gentamicin sulfate into the core, an ultrasonic welder was used to seal the capsule. An elution method and an high-performance liquid chromatography assay were employed to characterize the in vitro release rates of the antibiotics over a 30-day period. It was found that biodegradable capsules released high concentration of vancomycin and gentamicin (well above the minimum inhibition concentration) in vitro for the period of time needed to treat bone infection; i.e., 2–4 weeks. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 3 to 18
mm, which is equivalent to 16.7–100% of relative activity. By adopting this novel technique, we will be able to manufacture biodegradable capsules of various medicines for long-term drug delivery.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2004.11.053</identifier><identifier>PMID: 15722136</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Antibiotic capsules ; Bacterial inhibition ; Biodegradation, Environmental ; Compression sintering ; Delayed-Action Preparations ; Gentamicins - administration & dosage ; Gentamicins - pharmacokinetics ; Gentamicins - pharmacology ; In vitro elution ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; PLGA ; Solvents ; Ultrasonic welding ; Vancomycin - administration & dosage ; Vancomycin - pharmacokinetics ; Vancomycin - pharmacology</subject><ispartof>Biomaterials, 2005-08, Vol.26 (22), p.4662-4669</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-632a2b93ae80c56df854dff06dc7359aab2087da6cf7d627b76e687001f68f523</citedby><cites>FETCH-LOGICAL-c471t-632a2b93ae80c56df854dff06dc7359aab2087da6cf7d627b76e687001f68f523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2004.11.053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15722136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Shih-Jung</creatorcontrib><creatorcontrib>Tsai, Ying-E</creatorcontrib><creatorcontrib>Wen-Neng Ueng, Steve</creatorcontrib><creatorcontrib>Chan, Err-Cheng</creatorcontrib><title>A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>This report was to develop a novel solvent-free method for the manufacture of biodegradable capsules for a long-term drug delivery. To manufacture an antibiotic capsule, polylactide–polyglycolide copolymers were pre-mixed with vancomycin. The mixture was then injection compression molded to form a cylinder with a cover of 8
mm in diameter. After the addition of gentamicin sulfate into the core, an ultrasonic welder was used to seal the capsule. An elution method and an high-performance liquid chromatography assay were employed to characterize the in vitro release rates of the antibiotics over a 30-day period. It was found that biodegradable capsules released high concentration of vancomycin and gentamicin (well above the minimum inhibition concentration) in vitro for the period of time needed to treat bone infection; i.e., 2–4 weeks. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 3 to 18
mm, which is equivalent to 16.7–100% of relative activity. By adopting this novel technique, we will be able to manufacture biodegradable capsules of various medicines for long-term drug delivery.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic capsules</subject><subject>Bacterial inhibition</subject><subject>Biodegradation, Environmental</subject><subject>Compression sintering</subject><subject>Delayed-Action Preparations</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - pharmacokinetics</subject><subject>Gentamicins - pharmacology</subject><subject>In vitro elution</subject><subject>Microbial Sensitivity Tests</subject><subject>Microscopy, Electron, Scanning</subject><subject>PLGA</subject><subject>Solvents</subject><subject>Ultrasonic welding</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - pharmacokinetics</subject><subject>Vancomycin - pharmacology</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUs2OFCEY7BiNO66-giEevHULdAM93jarriabeNEzoeFjhgkNI9Bj9ql8RWlnEr2tJ_JVqqjvp5rmDcEdwYS_O3STi7MqkJzyuaMYDx0hHWb9k2ZDRjG2bIvZ02aDyUDbLSf0qnmR8wHXGg_0eXNFmKCU9HzT_LpBIZ7Aoxz9CUJpbQJAM5R9NMjGhMq-liosVumyJEDRoupuYJeUUZMHpEJxFSlOt1od8-Ih_xEq5GPYtbXLGZm07FACDyoDWrILO6TjfEyQs4sBVWAdpqIqGLT4klSOwWn0E7xZ4QJ6H9yPBfLL5pmtQ8Ory3vdfP_08dvt5_b-692X25v7Vg-ClJb3VNFp2ysYsWbc2JENxlrMjRY92yo1UTwKo7i2wnAqJsGBj6JuyPLRMtpfN2_P_x5TXH2LnF3W4L0KEJcs6Zb1jAn-OHFkrKccP0okgtXb0bES35-JOsWcE1h5TG5W6UESLNcAyIP8NwByDYAkRNYAVPHri8syzWD-Si8Xr4QPZwLU7Z0cJJm1g6DBuAS6SBPd__j8BrPMza8</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Liu, Shih-Jung</creator><creator>Tsai, Ying-E</creator><creator>Wen-Neng Ueng, Steve</creator><creator>Chan, Err-Cheng</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>F28</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20050801</creationdate><title>A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques</title><author>Liu, Shih-Jung ; Tsai, Ying-E ; Wen-Neng Ueng, Steve ; Chan, Err-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-632a2b93ae80c56df854dff06dc7359aab2087da6cf7d627b76e687001f68f523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic capsules</topic><topic>Bacterial inhibition</topic><topic>Biodegradation, Environmental</topic><topic>Compression sintering</topic><topic>Delayed-Action Preparations</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - pharmacokinetics</topic><topic>Gentamicins - pharmacology</topic><topic>In vitro elution</topic><topic>Microbial Sensitivity Tests</topic><topic>Microscopy, Electron, Scanning</topic><topic>PLGA</topic><topic>Solvents</topic><topic>Ultrasonic welding</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - pharmacokinetics</topic><topic>Vancomycin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Shih-Jung</creatorcontrib><creatorcontrib>Tsai, Ying-E</creatorcontrib><creatorcontrib>Wen-Neng Ueng, Steve</creatorcontrib><creatorcontrib>Chan, Err-Cheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Shih-Jung</au><au>Tsai, Ying-E</au><au>Wen-Neng Ueng, Steve</au><au>Chan, Err-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>26</volume><issue>22</issue><spage>4662</spage><epage>4669</epage><pages>4662-4669</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>This report was to develop a novel solvent-free method for the manufacture of biodegradable capsules for a long-term drug delivery. To manufacture an antibiotic capsule, polylactide–polyglycolide copolymers were pre-mixed with vancomycin. The mixture was then injection compression molded to form a cylinder with a cover of 8
mm in diameter. After the addition of gentamicin sulfate into the core, an ultrasonic welder was used to seal the capsule. An elution method and an high-performance liquid chromatography assay were employed to characterize the in vitro release rates of the antibiotics over a 30-day period. It was found that biodegradable capsules released high concentration of vancomycin and gentamicin (well above the minimum inhibition concentration) in vitro for the period of time needed to treat bone infection; i.e., 2–4 weeks. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 3 to 18
mm, which is equivalent to 16.7–100% of relative activity. By adopting this novel technique, we will be able to manufacture biodegradable capsules of various medicines for long-term drug delivery.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15722136</pmid><doi>10.1016/j.biomaterials.2004.11.053</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biomaterials, 2005-08, Vol.26 (22), p.4662-4669 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibiotic capsules Bacterial inhibition Biodegradation, Environmental Compression sintering Delayed-Action Preparations Gentamicins - administration & dosage Gentamicins - pharmacokinetics Gentamicins - pharmacology In vitro elution Microbial Sensitivity Tests Microscopy, Electron, Scanning PLGA Solvents Ultrasonic welding Vancomycin - administration & dosage Vancomycin - pharmacokinetics Vancomycin - pharmacology |
| title | A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques |
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