Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane
The interaction of chlorpromazine (CPZ) with supported bilayer lipid (dipalmitoyphosphatidylcholine) membrane (s-BLM) on the glassy carbon electrode (GCE) was investigated using cyclic voltammetry and ac impedance spectroscopy. The experimental data, based on the voltammetric response of Ru(NH 3) 6...
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| Veröffentlicht in: | Electrochimica acta 2006-02, Vol.51 (12), p.2512-2517 |
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| container_issue | 12 |
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| container_title | Electrochimica acta |
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| creator | Liu, Xiaohua Bai, Haixin Huang, Weimin Du, Liangwei Yang, Xiurong Wang, Erkang |
| description | The interaction of chlorpromazine (CPZ) with supported bilayer lipid (dipalmitoyphosphatidylcholine) membrane (s-BLM) on the glassy carbon electrode (GCE) was investigated using cyclic voltammetry and ac impedance spectroscopy. The experimental data, based on the voltammetric response of Ru(NH
3)
6
3+ associated with the oxidation of CPZ on the electrode, indicated that the interaction of CPZ with s-BLM was concentration and time dependant. The interaction between them could be divided into three stages by the concentration of CPZ: low, middle and high concentration. At the first stage, s-BLM was not affected by CPZ and the interaction was only a penetration of a small quantity of CPZ molecule into s-BLM. At the second stage, the defects formed in s-BLM due to the penetration of more CPZ molecule into s-BLM. At the last stage, a high CPZ:lipid ratio reached in s-BLM, resulting in the solubilization of s-BLM. The interaction time had different effect at three stages. |
| doi_str_mv | 10.1016/j.electacta.2005.07.034 |
| format | Article |
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3)
6
3+ associated with the oxidation of CPZ on the electrode, indicated that the interaction of CPZ with s-BLM was concentration and time dependant. The interaction between them could be divided into three stages by the concentration of CPZ: low, middle and high concentration. At the first stage, s-BLM was not affected by CPZ and the interaction was only a penetration of a small quantity of CPZ molecule into s-BLM. At the second stage, the defects formed in s-BLM due to the penetration of more CPZ molecule into s-BLM. At the last stage, a high CPZ:lipid ratio reached in s-BLM, resulting in the solubilization of s-BLM. The interaction time had different effect at three stages.</description><identifier>ISSN: 0013-4686</identifier><identifier>EISSN: 1873-3859</identifier><identifier>DOI: 10.1016/j.electacta.2005.07.034</identifier><identifier>CODEN: ELCAAV</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>ac impedance spectroscopy ; Biological and medical sciences ; Chlorpromazine ; Cyclic voltammetry ; General pharmacology ; Interaction ; Medical sciences ; Oxidation ; Pharmacology. Drug treatments ; Physicochemical properties. Structure-activity relationships ; Supported bilayer lipid membrane</subject><ispartof>Electrochimica acta, 2006-02, Vol.51 (12), p.2512-2517</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-595614a53bd6b8335f9ffc1939c2cabf41d6f0db4c29fd13b01d7f4c0c09e4c43</citedby><cites>FETCH-LOGICAL-c376t-595614a53bd6b8335f9ffc1939c2cabf41d6f0db4c29fd13b01d7f4c0c09e4c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.electacta.2005.07.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17560943$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xiaohua</creatorcontrib><creatorcontrib>Bai, Haixin</creatorcontrib><creatorcontrib>Huang, Weimin</creatorcontrib><creatorcontrib>Du, Liangwei</creatorcontrib><creatorcontrib>Yang, Xiurong</creatorcontrib><creatorcontrib>Wang, Erkang</creatorcontrib><title>Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane</title><title>Electrochimica acta</title><description>The interaction of chlorpromazine (CPZ) with supported bilayer lipid (dipalmitoyphosphatidylcholine) membrane (s-BLM) on the glassy carbon electrode (GCE) was investigated using cyclic voltammetry and ac impedance spectroscopy. The experimental data, based on the voltammetric response of Ru(NH
3)
6
3+ associated with the oxidation of CPZ on the electrode, indicated that the interaction of CPZ with s-BLM was concentration and time dependant. The interaction between them could be divided into three stages by the concentration of CPZ: low, middle and high concentration. At the first stage, s-BLM was not affected by CPZ and the interaction was only a penetration of a small quantity of CPZ molecule into s-BLM. At the second stage, the defects formed in s-BLM due to the penetration of more CPZ molecule into s-BLM. At the last stage, a high CPZ:lipid ratio reached in s-BLM, resulting in the solubilization of s-BLM. The interaction time had different effect at three stages.</description><subject>ac impedance spectroscopy</subject><subject>Biological and medical sciences</subject><subject>Chlorpromazine</subject><subject>Cyclic voltammetry</subject><subject>General pharmacology</subject><subject>Interaction</subject><subject>Medical sciences</subject><subject>Oxidation</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Supported bilayer lipid membrane</subject><issn>0013-4686</issn><issn>1873-3859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkE-LFDEQxYOs4OzqZzAXvXVb6aQ7k-My-A8WvOg5pJMKk6E7aZPMyvrpzTCLHoWCurxXr96PkLcMegZs-nDqcUFbTZt-ABh7kD1w8YLs2F7yju9HdUN2AIx3YtpPr8htKScAkJOEHVkPKVqMNZsaUqQmOlrDitThhtGZWOmMR_MYUqbJU3tcUt5yWs3vEJGGWDG34IvzV6hHWs7blnJFR-ewmCfMdAlbcHTFdc4m4mvy0pul4JvnfUd-fPr4_fCle_j2-evh_qGzXE61G9U4MWFGPrtp3nM-euW9ZYorO1gze8Hc5MHNwg7KO8ZnYE56YcGCQmEFvyPvr3fbrz_PWKpeQ7G4LO2HdC56UCMXUgxNKK9Cm1MpGb3eclhNftIM9AWvPum_ePUFrwapG97mfPccYYo1i2_1bCj_7HKcQAnedPdXHba-jwGzLjZgY-5Cbne1S-G_WX8Az--YPQ</recordid><startdate>20060225</startdate><enddate>20060225</enddate><creator>Liu, Xiaohua</creator><creator>Bai, Haixin</creator><creator>Huang, Weimin</creator><creator>Du, Liangwei</creator><creator>Yang, Xiurong</creator><creator>Wang, Erkang</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20060225</creationdate><title>Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane</title><author>Liu, Xiaohua ; Bai, Haixin ; Huang, Weimin ; Du, Liangwei ; Yang, Xiurong ; Wang, Erkang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-595614a53bd6b8335f9ffc1939c2cabf41d6f0db4c29fd13b01d7f4c0c09e4c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ac impedance spectroscopy</topic><topic>Biological and medical sciences</topic><topic>Chlorpromazine</topic><topic>Cyclic voltammetry</topic><topic>General pharmacology</topic><topic>Interaction</topic><topic>Medical sciences</topic><topic>Oxidation</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Supported bilayer lipid membrane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiaohua</creatorcontrib><creatorcontrib>Bai, Haixin</creatorcontrib><creatorcontrib>Huang, Weimin</creatorcontrib><creatorcontrib>Du, Liangwei</creatorcontrib><creatorcontrib>Yang, Xiurong</creatorcontrib><creatorcontrib>Wang, Erkang</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electrochimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiaohua</au><au>Bai, Haixin</au><au>Huang, Weimin</au><au>Du, Liangwei</au><au>Yang, Xiurong</au><au>Wang, Erkang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane</atitle><jtitle>Electrochimica acta</jtitle><date>2006-02-25</date><risdate>2006</risdate><volume>51</volume><issue>12</issue><spage>2512</spage><epage>2517</epage><pages>2512-2517</pages><issn>0013-4686</issn><eissn>1873-3859</eissn><coden>ELCAAV</coden><abstract>The interaction of chlorpromazine (CPZ) with supported bilayer lipid (dipalmitoyphosphatidylcholine) membrane (s-BLM) on the glassy carbon electrode (GCE) was investigated using cyclic voltammetry and ac impedance spectroscopy. The experimental data, based on the voltammetric response of Ru(NH
3)
6
3+ associated with the oxidation of CPZ on the electrode, indicated that the interaction of CPZ with s-BLM was concentration and time dependant. The interaction between them could be divided into three stages by the concentration of CPZ: low, middle and high concentration. At the first stage, s-BLM was not affected by CPZ and the interaction was only a penetration of a small quantity of CPZ molecule into s-BLM. At the second stage, the defects formed in s-BLM due to the penetration of more CPZ molecule into s-BLM. At the last stage, a high CPZ:lipid ratio reached in s-BLM, resulting in the solubilization of s-BLM. The interaction time had different effect at three stages.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.electacta.2005.07.034</doi><tpages>6</tpages></addata></record> |
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| subjects | ac impedance spectroscopy Biological and medical sciences Chlorpromazine Cyclic voltammetry General pharmacology Interaction Medical sciences Oxidation Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Supported bilayer lipid membrane |
| title | Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane |
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