Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography/electrospray ionization mass spectrometry

Bilirubin is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, bilirubin accumulates and may cause severe neurotoxicity. Degradation of bilirubin takes place (a) on interaction with oxidative free radicals and (b) when cytochr...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2006-01, Vol.20 (8), p.1209-1217
Hauptverfasser:	De Matteis, Francesco, Lord, Gwyn A., Kee Lim, Chang, Pons, Nicoletta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - chemistry Chick Embryo Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - chemistry Nucleotides - chemistry Oxidation-Reduction Pyridines - chemistry Spectrometry, Mass, Electrospray Ionization
Online-Zugang:	Volltext
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