Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer’s disease

•GPR139 activation in the brain ameliorated Aβ1-42-induced cognitive impairment.•GPR139 activation alleviated Aβ1-42-induced apoptosis and synaptotoxicity in the basal forebrain.•GPR139 overexpression in the MS ameliorated cognitive impairment in APP/PS1 mice.•GPR139 overexpression in the MS allevia...

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Veröffentlicht in:	International immunopharmacology 2024-03, Vol.130, p.111786-111786, Article 111786
Hauptverfasser:	Mu, Ronghao, Hou, Xiaoying, Liu, Qi, Wang, Wan, Qin, Chi, Li, Huixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cholinergic neurons Cognitive impairment G-protein coupled receptor 139 Medial septum Synaptotoxicity
Online-Zugang:	Volltext
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