Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia

Vincristine-induced peripheral neuropathy is a common side effect of vincristine treatment, which is accompanied by pain and can be dose-limiting. The molecular mechanisms that underlie vincristine-induced pain are not well understood. We have established an animal model to investigate pathophysiolo...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2024-09, Vol.147 (9), p.3157-3170
Hauptverfasser:	Nascimento de Lima, Ana Paula, Zhang, Huiran, Chen, Lubin, Effraim, Philip R, Gomis-Perez, Carolina, Cheng, Xiaoyang, Huang, Jianying, Waxman, Stephen G, Dib-Hajj, Sulayman D
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Antineoplastic Agents, Phytogenic - toxicity Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Hyperalgesia - chemically induced Hyperalgesia - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout NAV1.8 Voltage-Gated Sodium Channel - genetics NAV1.8 Voltage-Gated Sodium Channel - metabolism Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Tetrodotoxin - pharmacology Vincristine - pharmacology Vincristine - toxicity
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