Synthesis of trifluoroethoxy/aryloxy cinnolines, cinnolinones and indazoles from o -alkynylanilines via metal-free diazotization reagent

Synthesis of trifluoroethoxy/aryloxy cinnolines, cinnolinones and indazoles from o -alkynylanilines via metal-free diazotization reagent

A facile and user-friendly protocol for the synthesis of trifluoroethoxy/aryloxy cinnolines, cinnolinones and indazoles from -alkynylaniline in good-to-excellent yields has been developed using a metal-free diazotization reagent (a combination of BF ·OEt and TBN). The methodology has been further ex...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-03, Vol.22 (13), p.2608-2619
Hauptverfasser: Kumar, Madan, Goswami, Avijit
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Reagents
Synthesis
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Goswami, Avijit
description A facile and user-friendly protocol for the synthesis of trifluoroethoxy/aryloxy cinnolines, cinnolinones and indazoles from -alkynylaniline in good-to-excellent yields has been developed using a metal-free diazotization reagent (a combination of BF ·OEt and TBN). The methodology has been further extended to construct bis-cinnolinones and for the chemoselective synthesis of -propargylated cinnolinones.
doi_str_mv 10.1039/d4ob00058g
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Reagents
Synthesis
title Synthesis of trifluoroethoxy/aryloxy cinnolines, cinnolinones and indazoles from o -alkynylanilines via metal-free diazotization reagent
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