Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue
Objective To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals. Subjects and methods Three groups of subjects participated: one group consist...
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| Veröffentlicht in: | Clinical oral investigations 2024-03, Vol.28 (3), p.199-199, Article 199 |
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| creator | Kayar, Nezahat Arzu Çelik, İlhami Gözlü, Muammer Üstün, Kemal Gürsel, Mihtikar Alptekin, Nilgün Özlem |
| description | Objective
To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals.
Subjects and methods
Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically.
Results
Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G;
p
ACS + P > no ACS + G;
p
no ACS + P and ACS + P > no ACS + G;
p
|
| doi_str_mv | 10.1007/s00784-023-05448-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2942187044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2942187044</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-8ab214fd3bf15391ae0e258b1f1920f8ec4adf71b4ef448dd40bdd3e838c2a3e3</originalsourceid><addsrcrecordid>eNp9kT1PHDEQhq0IFD6SP5ACWaKJFC2x117so0NH-JCQaEhtedfjlWHXvtjrk-jSovxLfgm-3AUiCgrbM_Iz74zmRegLJUeUEPE9lUvyitSsIg3nshIf0C7l7LhiQtCt_-IdtJfSHSGUHwv2Ee0wyRvKSLOL_lyNY_ZhCL3rcJujAY8H5-8TXkB0wQQ_ucklPAWsuzwB7kIMXscHnB68iWGEEzzAEoaEg8XzM_70-_FbOdqbkslNdos7GAriPO6d791SD7iP2udBTy54XDqkDJ_QttVDgs-bdx_9PP9xO7-srm8uruan11XHBJkqqduacmtYa2nDZlQDgbqRLbV0VhMroePaWEFbDrZsxRhOWmMYSCa7WjNg--jrWncRw68MaVKjS6sBtYeQk6pnvKZSEM4LevgGvQs5-jLdiiKzpilsoeo11cWQUgSrFtGNZUmKErWySq2tUsUq9dcqJUrRwUY6tyOYl5J_3hSArYFUvnwP8bX3O7LP5Yqj-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2940955942</pqid></control><display><type>article</type><title>Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kayar, Nezahat Arzu ; Çelik, İlhami ; Gözlü, Muammer ; Üstün, Kemal ; Gürsel, Mihtikar ; Alptekin, Nilgün Özlem</creator><creatorcontrib>Kayar, Nezahat Arzu ; Çelik, İlhami ; Gözlü, Muammer ; Üstün, Kemal ; Gürsel, Mihtikar ; Alptekin, Nilgün Özlem</creatorcontrib><description><![CDATA[Objective
To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals.
Subjects and methods
Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically.
Results
Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G;
p
< 0.05) and CD8 + T-lymphocytes (no ACS + P > ACS + P > no ACS + G;
p
< 0.05). Significant variations were observed between the groups both CD4 + T-lymphocytes densities (ACS + P > no ACS + P and ACS + P > no ACS + G;
p
< 0.05) and CD4 + / CD8 + ratio (no ACS + P < no ACS + G and ACS + P < no ACS + G;
p
< 0.05).
Conclusions
The increased number of CD8 + T-lymphocytes in both group ACS + P and group no ACS + P resulted in a reduction of the CD4 + /CD8 + ratio in gingival tissue when compared with no ACS + G group.
Clinical relevance
The decrease of CD4 + /CD8 + ratio in gingival tissue reflects periodontitis and may be associated with severe adverse outcomes in people with ACS.]]></description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-023-05448-7</identifier><identifier>PMID: 38451305</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute Coronary Syndrome - immunology ; Acute coronary syndromes ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Dentistry ; Gingiva ; Gingivitis ; Granulation Tissue ; Gum disease ; Humans ; Lymphocytes ; Lymphocytes T ; Macrophages ; Medicine ; Periodontics ; Periodontitis ; Periodontitis - immunology</subject><ispartof>Clinical oral investigations, 2024-03, Vol.28 (3), p.199-199, Article 199</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-8ab214fd3bf15391ae0e258b1f1920f8ec4adf71b4ef448dd40bdd3e838c2a3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-023-05448-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-023-05448-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38451305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kayar, Nezahat Arzu</creatorcontrib><creatorcontrib>Çelik, İlhami</creatorcontrib><creatorcontrib>Gözlü, Muammer</creatorcontrib><creatorcontrib>Üstün, Kemal</creatorcontrib><creatorcontrib>Gürsel, Mihtikar</creatorcontrib><creatorcontrib>Alptekin, Nilgün Özlem</creatorcontrib><title>Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description><![CDATA[Objective
To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals.
Subjects and methods
Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically.
Results
Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G;
p
< 0.05) and CD8 + T-lymphocytes (no ACS + P > ACS + P > no ACS + G;
p
< 0.05). Significant variations were observed between the groups both CD4 + T-lymphocytes densities (ACS + P > no ACS + P and ACS + P > no ACS + G;
p
< 0.05) and CD4 + / CD8 + ratio (no ACS + P < no ACS + G and ACS + P < no ACS + G;
p
< 0.05).
Conclusions
The increased number of CD8 + T-lymphocytes in both group ACS + P and group no ACS + P resulted in a reduction of the CD4 + /CD8 + ratio in gingival tissue when compared with no ACS + G group.
Clinical relevance
The decrease of CD4 + /CD8 + ratio in gingival tissue reflects periodontitis and may be associated with severe adverse outcomes in people with ACS.]]></description><subject>Acute Coronary Syndrome - immunology</subject><subject>Acute coronary syndromes</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Dentistry</subject><subject>Gingiva</subject><subject>Gingivitis</subject><subject>Granulation Tissue</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>Periodontics</subject><subject>Periodontitis</subject><subject>Periodontitis - immunology</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kT1PHDEQhq0IFD6SP5ACWaKJFC2x117so0NH-JCQaEhtedfjlWHXvtjrk-jSovxLfgm-3AUiCgrbM_Iz74zmRegLJUeUEPE9lUvyitSsIg3nshIf0C7l7LhiQtCt_-IdtJfSHSGUHwv2Ee0wyRvKSLOL_lyNY_ZhCL3rcJujAY8H5-8TXkB0wQQ_ucklPAWsuzwB7kIMXscHnB68iWGEEzzAEoaEg8XzM_70-_FbOdqbkslNdos7GAriPO6d791SD7iP2udBTy54XDqkDJ_QttVDgs-bdx_9PP9xO7-srm8uruan11XHBJkqqduacmtYa2nDZlQDgbqRLbV0VhMroePaWEFbDrZsxRhOWmMYSCa7WjNg--jrWncRw68MaVKjS6sBtYeQk6pnvKZSEM4LevgGvQs5-jLdiiKzpilsoeo11cWQUgSrFtGNZUmKErWySq2tUsUq9dcqJUrRwUY6tyOYl5J_3hSArYFUvnwP8bX3O7LP5Yqj-g</recordid><startdate>20240307</startdate><enddate>20240307</enddate><creator>Kayar, Nezahat Arzu</creator><creator>Çelik, İlhami</creator><creator>Gözlü, Muammer</creator><creator>Üstün, Kemal</creator><creator>Gürsel, Mihtikar</creator><creator>Alptekin, Nilgün Özlem</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240307</creationdate><title>Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue</title><author>Kayar, Nezahat Arzu ; Çelik, İlhami ; Gözlü, Muammer ; Üstün, Kemal ; Gürsel, Mihtikar ; Alptekin, Nilgün Özlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-8ab214fd3bf15391ae0e258b1f1920f8ec4adf71b4ef448dd40bdd3e838c2a3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Coronary Syndrome - immunology</topic><topic>Acute coronary syndromes</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Dentistry</topic><topic>Gingiva</topic><topic>Gingivitis</topic><topic>Granulation Tissue</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>Periodontics</topic><topic>Periodontitis</topic><topic>Periodontitis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kayar, Nezahat Arzu</creatorcontrib><creatorcontrib>Çelik, İlhami</creatorcontrib><creatorcontrib>Gözlü, Muammer</creatorcontrib><creatorcontrib>Üstün, Kemal</creatorcontrib><creatorcontrib>Gürsel, Mihtikar</creatorcontrib><creatorcontrib>Alptekin, Nilgün Özlem</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kayar, Nezahat Arzu</au><au>Çelik, İlhami</au><au>Gözlü, Muammer</au><au>Üstün, Kemal</au><au>Gürsel, Mihtikar</au><au>Alptekin, Nilgün Özlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2024-03-07</date><risdate>2024</risdate><volume>28</volume><issue>3</issue><spage>199</spage><epage>199</epage><pages>199-199</pages><artnum>199</artnum><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract><![CDATA[Objective
To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals.
Subjects and methods
Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically.
Results
Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G;
p
< 0.05) and CD8 + T-lymphocytes (no ACS + P > ACS + P > no ACS + G;
p
< 0.05). Significant variations were observed between the groups both CD4 + T-lymphocytes densities (ACS + P > no ACS + P and ACS + P > no ACS + G;
p
< 0.05) and CD4 + / CD8 + ratio (no ACS + P < no ACS + G and ACS + P < no ACS + G;
p
< 0.05).
Conclusions
The increased number of CD8 + T-lymphocytes in both group ACS + P and group no ACS + P resulted in a reduction of the CD4 + /CD8 + ratio in gingival tissue when compared with no ACS + G group.
Clinical relevance
The decrease of CD4 + /CD8 + ratio in gingival tissue reflects periodontitis and may be associated with severe adverse outcomes in people with ACS.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38451305</pmid><doi>10.1007/s00784-023-05448-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2024-03, Vol.28 (3), p.199-199, Article 199 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2942187044 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Acute Coronary Syndrome - immunology Acute coronary syndromes CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes Dentistry Gingiva Gingivitis Granulation Tissue Gum disease Humans Lymphocytes Lymphocytes T Macrophages Medicine Periodontics Periodontitis Periodontitis - immunology |
| title | Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue |
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