DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

Polycomb repressive complexes regulate developmental gene programs, promote DNA damage repair, and mediate pericentromeric satellite repeat repression. Expression of pericentromeric satellite repeats has been implicated in several cancers and diseases, including facioscapulohumeral dystrophy (FSHD)....

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Veröffentlicht in:	The Journal of cell biology 2024-05, Vol.223 (5), p.1
Hauptverfasser:	Arends, Tessa, Tsuchida, Hiroshi, Adeyemi, Richard O, Tapscott, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Cell Nucleus - genetics Damage Deoxyribonucleic acid DNA DNA damage DNA Repair Dystrophy Epigenetics Epigenomics F-Box Proteins - metabolism Histone H2A Histones - genetics Homeodomain Proteins - metabolism Humans Jumonji Domain-Containing Histone Demethylases - metabolism Multiprotein Complexes - metabolism Polycomb group proteins Ubiquitin Ubiquitination
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