Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide
Pregnancy hypertension-induced endothelial dysfunction associated with impairment of nitric oxide (NO) bioavailability and hemodynamic derangements is a challenging for urgent procedures requiring maternal anesthesia. The volatile anesthetic isoflurane has demonstrated NO-associated protective effec...
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| Veröffentlicht in: | Life sciences (1973) 2023-10, Vol.331, p.122039-122039, Article 122039 |
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| container_title | Life sciences (1973) |
| container_volume | 331 |
| creator | Rodrigues, Serginara David da Silva, Maria Luiza Santos Martins, Laisla Zanetoni Gomes, Sáskia Estela Biasotti Mariani, Noemia A.P. Silva, Erick J.R. Kushima, Hélio Mattos, Bruna Rahal Rizzi, Elen Dias-Junior, Carlos Alan |
| description | Pregnancy hypertension-induced endothelial dysfunction associated with impairment of nitric oxide (NO) bioavailability and hemodynamic derangements is a challenging for urgent procedures requiring maternal anesthesia. The volatile anesthetic isoflurane has demonstrated NO-associated protective effects. However, this isoflurane-induced effect is still unclear in pregnancy hypertension. Therefore, the present study examined the potential protective effects of isoflurane anesthesia on endothelial dysfunction and hemodynamic changes induced by hypertensive pregnancy associated with fetal and placental growth restrictions.
Animals were distributed into four groups: normotensive pregnant rats (Preg), anesthetized pregnant rats (Preg+Iso), hypertensive pregnant rats (HTN-Preg), and anesthetized hypertensive pregnant rats (HTN-Preg+Iso). Systolic and diastolic pressures, mean arterial pressure (MAP), heart rate, fetal and placental weights, vascular contraction, endothelium-derived NO-dependent vasodilation, and NO levels were assessed. The vascular endothelial growth factor (VEGF) levels and endothelial NO synthase (eNOS) Serine (1177) phosphorylation (p-eNOS) expression were also examined.
Isoflurane produced more expressive hypotensive effects in the HTN-Preg+Iso versus Preg+Iso group, with respective reductions in MAP by 50 ± 13 versus 25 ± 4 mmHg (P |
| doi_str_mv | 10.1016/j.lfs.2023.122039 |
| format | Article |
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Animals were distributed into four groups: normotensive pregnant rats (Preg), anesthetized pregnant rats (Preg+Iso), hypertensive pregnant rats (HTN-Preg), and anesthetized hypertensive pregnant rats (HTN-Preg+Iso). Systolic and diastolic pressures, mean arterial pressure (MAP), heart rate, fetal and placental weights, vascular contraction, endothelium-derived NO-dependent vasodilation, and NO levels were assessed. The vascular endothelial growth factor (VEGF) levels and endothelial NO synthase (eNOS) Serine (1177) phosphorylation (p-eNOS) expression were also examined.
Isoflurane produced more expressive hypotensive effects in the HTN-Preg+Iso versus Preg+Iso group, with respective reductions in MAP by 50 ± 13 versus 25 ± 4 mmHg (P < 0.05). Also, HTN-Preg+Iso compared to the HTN-Preg group showed (respectively) preventions against the weight loss of the fetuses (4.0 ± 0.6 versus 2.8 ± 0.6 g, P < 0.05) and placentas (0.37 ± 0.06 versus 0.30 ± 0.06 mg, P < 0.05), hyper-reactive vasocontraction response (1.8 ± 0.4 versus 2.8 ± 0.6 g, P < 0.05), impaired endothelium-derived NO-dependent vasodilation (84 ± 8 versus 50 ± 17 %, P < 0.05), reduced VEGF levels (147 ± 46 versus 25 ± 13 pg/mL, P < 0.05), and decreased p-eNOS expression (0.24 ± 0.07 versus 0.09 ± 0.05 arbitrary units, P < 0.05).
Isoflurane anesthesia protects maternal endothelial function in pregnancy hypertension, and possibly endothelium-derived NO is involved.
[Display omitted]]]></description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2023.122039</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Anesthesia ; bioavailability ; Endothelial dysfunction ; Gestational hypertension ; heart rate ; Hemodynamic derangements ; hypertension ; Isoflurane ; Nitric oxide ; phosphorylation ; pregnancy ; protective effect ; serine ; vascular endothelial growth factors ; vasodilation ; weight loss</subject><ispartof>Life sciences (1973), 2023-10, Vol.331, p.122039-122039, Article 122039</ispartof><rights>2023 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-7e811ddb0ad78c7595d95e8302ce31380fddf3757f0354253380582a2515e6693</citedby><cites>FETCH-LOGICAL-c363t-7e811ddb0ad78c7595d95e8302ce31380fddf3757f0354253380582a2515e6693</cites><orcidid>0000-0002-0348-6144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320523006744$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Rodrigues, Serginara David</creatorcontrib><creatorcontrib>da Silva, Maria Luiza Santos</creatorcontrib><creatorcontrib>Martins, Laisla Zanetoni</creatorcontrib><creatorcontrib>Gomes, Sáskia Estela Biasotti</creatorcontrib><creatorcontrib>Mariani, Noemia A.P.</creatorcontrib><creatorcontrib>Silva, Erick J.R.</creatorcontrib><creatorcontrib>Kushima, Hélio</creatorcontrib><creatorcontrib>Mattos, Bruna Rahal</creatorcontrib><creatorcontrib>Rizzi, Elen</creatorcontrib><creatorcontrib>Dias-Junior, Carlos Alan</creatorcontrib><title>Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide</title><title>Life sciences (1973)</title><description><![CDATA[Pregnancy hypertension-induced endothelial dysfunction associated with impairment of nitric oxide (NO) bioavailability and hemodynamic derangements is a challenging for urgent procedures requiring maternal anesthesia. The volatile anesthetic isoflurane has demonstrated NO-associated protective effects. However, this isoflurane-induced effect is still unclear in pregnancy hypertension. Therefore, the present study examined the potential protective effects of isoflurane anesthesia on endothelial dysfunction and hemodynamic changes induced by hypertensive pregnancy associated with fetal and placental growth restrictions.
Animals were distributed into four groups: normotensive pregnant rats (Preg), anesthetized pregnant rats (Preg+Iso), hypertensive pregnant rats (HTN-Preg), and anesthetized hypertensive pregnant rats (HTN-Preg+Iso). Systolic and diastolic pressures, mean arterial pressure (MAP), heart rate, fetal and placental weights, vascular contraction, endothelium-derived NO-dependent vasodilation, and NO levels were assessed. The vascular endothelial growth factor (VEGF) levels and endothelial NO synthase (eNOS) Serine (1177) phosphorylation (p-eNOS) expression were also examined.
Isoflurane produced more expressive hypotensive effects in the HTN-Preg+Iso versus Preg+Iso group, with respective reductions in MAP by 50 ± 13 versus 25 ± 4 mmHg (P < 0.05). Also, HTN-Preg+Iso compared to the HTN-Preg group showed (respectively) preventions against the weight loss of the fetuses (4.0 ± 0.6 versus 2.8 ± 0.6 g, P < 0.05) and placentas (0.37 ± 0.06 versus 0.30 ± 0.06 mg, P < 0.05), hyper-reactive vasocontraction response (1.8 ± 0.4 versus 2.8 ± 0.6 g, P < 0.05), impaired endothelium-derived NO-dependent vasodilation (84 ± 8 versus 50 ± 17 %, P < 0.05), reduced VEGF levels (147 ± 46 versus 25 ± 13 pg/mL, P < 0.05), and decreased p-eNOS expression (0.24 ± 0.07 versus 0.09 ± 0.05 arbitrary units, P < 0.05).
Isoflurane anesthesia protects maternal endothelial function in pregnancy hypertension, and possibly endothelium-derived NO is involved.
[Display omitted]]]></description><subject>Anesthesia</subject><subject>bioavailability</subject><subject>Endothelial dysfunction</subject><subject>Gestational hypertension</subject><subject>heart rate</subject><subject>Hemodynamic derangements</subject><subject>hypertension</subject><subject>Isoflurane</subject><subject>Nitric oxide</subject><subject>phosphorylation</subject><subject>pregnancy</subject><subject>protective effect</subject><subject>serine</subject><subject>vascular endothelial growth factors</subject><subject>vasodilation</subject><subject>weight loss</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkctuFDEQRS0EEkPgA9h5yaYHP8b9gBWKEogUCRawthy7TDzq2IPLPaL_hw-lJsOaLCyXSveU6tZl7K0UWylk_36_nSNulVB6K5USenrGNnIcpk70Wj5nGyHUrtNKmJfsFeJeCGHMoDfsz7cKP7PLfuX36wFqg4yp5M4hFp9cg8Ahh9LuYU5u5mHFuGTfSMITctdIvzyq7lZqlDgv1WXg9JAYTO4DvzqmANkDL5EfamlA-BE4xEgVrzA_8q3wlH0Fh4BU8ZxaTZ6X3wS_Zi-imxHe_Psv2I_rq--XX7rbr59vLj_ddl73unUDjFKGcCdcGEY_mMmEycCohfKgpR5FDCHqwQxRaLNTRlPLjMopIw30_aQv2LvzXFrz10IO7ENCD_NMdsqCVk07JYWmiU9LRzP1wkzTSSrPUl8LYoVoDzU9uLpaKewpPLu3FJ49hWfP4RHz8cwA2T0mqBZ9Oh0xpEpXs6Gk_9B_AaIEpV8</recordid><startdate>20231015</startdate><enddate>20231015</enddate><creator>Rodrigues, Serginara David</creator><creator>da Silva, Maria Luiza Santos</creator><creator>Martins, Laisla Zanetoni</creator><creator>Gomes, Sáskia Estela Biasotti</creator><creator>Mariani, Noemia A.P.</creator><creator>Silva, Erick J.R.</creator><creator>Kushima, Hélio</creator><creator>Mattos, Bruna Rahal</creator><creator>Rizzi, Elen</creator><creator>Dias-Junior, Carlos Alan</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-0348-6144</orcidid></search><sort><creationdate>20231015</creationdate><title>Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide</title><author>Rodrigues, Serginara David ; da Silva, Maria Luiza Santos ; Martins, Laisla Zanetoni ; Gomes, Sáskia Estela Biasotti ; Mariani, Noemia A.P. ; Silva, Erick J.R. ; Kushima, Hélio ; Mattos, Bruna Rahal ; Rizzi, Elen ; Dias-Junior, Carlos Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-7e811ddb0ad78c7595d95e8302ce31380fddf3757f0354253380582a2515e6693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anesthesia</topic><topic>bioavailability</topic><topic>Endothelial dysfunction</topic><topic>Gestational hypertension</topic><topic>heart rate</topic><topic>Hemodynamic derangements</topic><topic>hypertension</topic><topic>Isoflurane</topic><topic>Nitric oxide</topic><topic>phosphorylation</topic><topic>pregnancy</topic><topic>protective effect</topic><topic>serine</topic><topic>vascular endothelial growth factors</topic><topic>vasodilation</topic><topic>weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigues, Serginara David</creatorcontrib><creatorcontrib>da Silva, Maria Luiza Santos</creatorcontrib><creatorcontrib>Martins, Laisla Zanetoni</creatorcontrib><creatorcontrib>Gomes, Sáskia Estela Biasotti</creatorcontrib><creatorcontrib>Mariani, Noemia A.P.</creatorcontrib><creatorcontrib>Silva, Erick J.R.</creatorcontrib><creatorcontrib>Kushima, Hélio</creatorcontrib><creatorcontrib>Mattos, Bruna Rahal</creatorcontrib><creatorcontrib>Rizzi, Elen</creatorcontrib><creatorcontrib>Dias-Junior, Carlos Alan</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues, Serginara David</au><au>da Silva, Maria Luiza Santos</au><au>Martins, Laisla Zanetoni</au><au>Gomes, Sáskia Estela Biasotti</au><au>Mariani, Noemia A.P.</au><au>Silva, Erick J.R.</au><au>Kushima, Hélio</au><au>Mattos, Bruna Rahal</au><au>Rizzi, Elen</au><au>Dias-Junior, Carlos Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide</atitle><jtitle>Life sciences (1973)</jtitle><date>2023-10-15</date><risdate>2023</risdate><volume>331</volume><spage>122039</spage><epage>122039</epage><pages>122039-122039</pages><artnum>122039</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract><![CDATA[Pregnancy hypertension-induced endothelial dysfunction associated with impairment of nitric oxide (NO) bioavailability and hemodynamic derangements is a challenging for urgent procedures requiring maternal anesthesia. The volatile anesthetic isoflurane has demonstrated NO-associated protective effects. However, this isoflurane-induced effect is still unclear in pregnancy hypertension. Therefore, the present study examined the potential protective effects of isoflurane anesthesia on endothelial dysfunction and hemodynamic changes induced by hypertensive pregnancy associated with fetal and placental growth restrictions.
Animals were distributed into four groups: normotensive pregnant rats (Preg), anesthetized pregnant rats (Preg+Iso), hypertensive pregnant rats (HTN-Preg), and anesthetized hypertensive pregnant rats (HTN-Preg+Iso). Systolic and diastolic pressures, mean arterial pressure (MAP), heart rate, fetal and placental weights, vascular contraction, endothelium-derived NO-dependent vasodilation, and NO levels were assessed. The vascular endothelial growth factor (VEGF) levels and endothelial NO synthase (eNOS) Serine (1177) phosphorylation (p-eNOS) expression were also examined.
Isoflurane produced more expressive hypotensive effects in the HTN-Preg+Iso versus Preg+Iso group, with respective reductions in MAP by 50 ± 13 versus 25 ± 4 mmHg (P < 0.05). Also, HTN-Preg+Iso compared to the HTN-Preg group showed (respectively) preventions against the weight loss of the fetuses (4.0 ± 0.6 versus 2.8 ± 0.6 g, P < 0.05) and placentas (0.37 ± 0.06 versus 0.30 ± 0.06 mg, P < 0.05), hyper-reactive vasocontraction response (1.8 ± 0.4 versus 2.8 ± 0.6 g, P < 0.05), impaired endothelium-derived NO-dependent vasodilation (84 ± 8 versus 50 ± 17 %, P < 0.05), reduced VEGF levels (147 ± 46 versus 25 ± 13 pg/mL, P < 0.05), and decreased p-eNOS expression (0.24 ± 0.07 versus 0.09 ± 0.05 arbitrary units, P < 0.05).
Isoflurane anesthesia protects maternal endothelial function in pregnancy hypertension, and possibly endothelium-derived NO is involved.
[Display omitted]]]></abstract><pub>Elsevier Inc</pub><doi>10.1016/j.lfs.2023.122039</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0348-6144</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Anesthesia bioavailability Endothelial dysfunction Gestational hypertension heart rate Hemodynamic derangements hypertension Isoflurane Nitric oxide phosphorylation pregnancy protective effect serine vascular endothelial growth factors vasodilation weight loss |
| title | Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide |
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