Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate
High consumption of locally produced delicacies could expose nursing mothers to high monosodium glutamate (MSG) levels, frequently used as a necessary condiment in low-income countries. Thus, this study evaluated some novel preliminary changes in renal hormonal receptors, the aquaporin-3 channel, ox...
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| description | High consumption of locally produced delicacies could expose nursing mothers to high monosodium glutamate (MSG) levels, frequently used as a necessary condiment in low-income countries. Thus, this study evaluated some novel preliminary changes in renal hormonal receptors, the aquaporin-3 channel, oxidative stress markers, and hematological indices induced by monosodium glutamate in lactating rats. Post-parturition, twenty-four (24) lactating Wistar rats were divided into four (4) groups of six rats each (
n
= 6). Oral administration of distilled water and MSG started three (3) days postpartum as follows: group 1: distilled water (1 ml/kg BW), group 2: MSG (925 mg/kg BW), group 3: MSG (1850 mg/kg BW), and group 4: MSG (3700 mg/kg BW). At the end of the experiment, which lasted fourteen (14) days, animals were sacrificed and samples of blood and tissues were obtained for biochemical analysis. MSG administration significantly (
p
|
| doi_str_mv | 10.1007/s00210-024-03008-8 |
| format | Article |
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n
= 6). Oral administration of distilled water and MSG started three (3) days postpartum as follows: group 1: distilled water (1 ml/kg BW), group 2: MSG (925 mg/kg BW), group 3: MSG (1850 mg/kg BW), and group 4: MSG (3700 mg/kg BW). At the end of the experiment, which lasted fourteen (14) days, animals were sacrificed and samples of blood and tissues were obtained for biochemical analysis. MSG administration significantly (
p
< 0.05) increased ROS and MDA, with a significant (
p
< 0.05) decrease in kidney antioxidants. Serum creatinine, total, conjugated, and unconjugated bilirubin significantly (
p
< 0.05) increased with MSG administration. The prolactin receptor was significantly reduced (
p
< 0.05), while the oxytocin receptor and aquaporin-3 channel were significantly (
p
< 0.05) increased in the MSG-administered groups. There were significant (
p
< 0.05) changes in the hematological indices of the MSG-administered animals. Thus, the findings of this study suggest that high MSG consumption causes hematological alterations and may alter renal function via increased ROS production and dysregulation of the AQP-3 channel, prolactin, and oxytocin receptors in the kidneys of lactating Wistar rats.]]></description><identifier>ISSN: 0028-1298</identifier><identifier>ISSN: 1432-1912</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-024-03008-8</identifier><identifier>PMID: 38446217</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Aquaporin 3 - metabolism ; Aquaporins ; Bilirubin ; Biochemical analysis ; Biomedical and Life Sciences ; Biomedicine ; Creatinine ; Female ; Hematology ; Hormones ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Lactation ; Monosodium glutamate ; Neurosciences ; Oral administration ; Oxidative stress ; Oxidative Stress - drug effects ; Oxytocin ; Oxytocin receptors ; Parturition ; Pharmacology/Toxicology ; Prolactin ; Prolactin - blood ; Prolactin - metabolism ; Rats ; Rats, Wistar ; Receptor mechanisms ; Receptors, Oxytocin - metabolism ; Renal function ; Sodium Glutamate - toxicity</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2024-08, Vol.397 (8), p.6213-6229</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-e31a3c7afecaf0687e2117b816039d6ea21664758d6f8a039f3fb4d11ed6b2e23</cites><orcidid>0000-0002-9119-8870 ; 0000-0002-0459-2141 ; 0000-0002-9348-3966</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-024-03008-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-024-03008-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38446217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emmanuel, Nachamada Solomon</creatorcontrib><creatorcontrib>Yusuf, Tanko</creatorcontrib><creatorcontrib>Bako, Ibrahim Gaya</creatorcontrib><creatorcontrib>Malgwi, Ibrahim Samaila</creatorcontrib><creatorcontrib>Eze, Ejike Daniel</creatorcontrib><creatorcontrib>Ali, Zubairu</creatorcontrib><creatorcontrib>Aliyu, Mohammed</creatorcontrib><title>Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description><![CDATA[High consumption of locally produced delicacies could expose nursing mothers to high monosodium glutamate (MSG) levels, frequently used as a necessary condiment in low-income countries. Thus, this study evaluated some novel preliminary changes in renal hormonal receptors, the aquaporin-3 channel, oxidative stress markers, and hematological indices induced by monosodium glutamate in lactating rats. Post-parturition, twenty-four (24) lactating Wistar rats were divided into four (4) groups of six rats each (
n
= 6). Oral administration of distilled water and MSG started three (3) days postpartum as follows: group 1: distilled water (1 ml/kg BW), group 2: MSG (925 mg/kg BW), group 3: MSG (1850 mg/kg BW), and group 4: MSG (3700 mg/kg BW). At the end of the experiment, which lasted fourteen (14) days, animals were sacrificed and samples of blood and tissues were obtained for biochemical analysis. MSG administration significantly (
p
< 0.05) increased ROS and MDA, with a significant (
p
< 0.05) decrease in kidney antioxidants. Serum creatinine, total, conjugated, and unconjugated bilirubin significantly (
p
< 0.05) increased with MSG administration. The prolactin receptor was significantly reduced (
p
< 0.05), while the oxytocin receptor and aquaporin-3 channel were significantly (
p
< 0.05) increased in the MSG-administered groups. There were significant (
p
< 0.05) changes in the hematological indices of the MSG-administered animals. Thus, the findings of this study suggest that high MSG consumption causes hematological alterations and may alter renal function via increased ROS production and dysregulation of the AQP-3 channel, prolactin, and oxytocin receptors in the kidneys of lactating Wistar rats.]]></description><subject>Animals</subject><subject>Aquaporin 3 - metabolism</subject><subject>Aquaporins</subject><subject>Bilirubin</subject><subject>Biochemical analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Creatinine</subject><subject>Female</subject><subject>Hematology</subject><subject>Hormones</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Lactation</subject><subject>Monosodium glutamate</subject><subject>Neurosciences</subject><subject>Oral administration</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxytocin</subject><subject>Oxytocin receptors</subject><subject>Parturition</subject><subject>Pharmacology/Toxicology</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor mechanisms</subject><subject>Receptors, Oxytocin - metabolism</subject><subject>Renal function</subject><subject>Sodium Glutamate - toxicity</subject><issn>0028-1298</issn><issn>1432-1912</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEokvhBTggS1w4bMB_so73iCpokSpxAXG0ZuNJ6pLYW48D3QfkveptCkgcOI3s-c03n_1V1UvB3wrO23fEuRS85rKpueLc1OZRtRKNkrXYCvm4WpW-qYXcmpPqGdE151yLzeZpdaJM02gp2lX16wInyHGMg-9gZN0VhAFpzeKtd5D9D2SUExIxICplwpDXDIJj7kAJh3ksUAws9gxuZtjH5EOt7mUCjmu2T3GELvuwDMXbQ46dDyxhh_scE7Fy-O5dwAMdRY5wUQwD--YpQ2IJMrHiADI69tPnKzbFECk6P09sGOcMxT4-r570MBK-eKin1dePH76cXdSXn88_nb2_rDslda5RCVBdCz120HNtWpRCtDsjNFdbpxGk0LppN8bp3kC561W_a5wQ6PROolSn1ZtFt7zrZkbKdvLU4ThCwDiTlVtlpGml3hT09T_odZxTKO6s4lul27aAhZIL1aVI5UN7u09-gnSwgttjyHYJ2ZaQ7X3I1pShVw_S825C92fkd6oFUAtApVXyTH93_0f2DtJUty0</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Emmanuel, Nachamada Solomon</creator><creator>Yusuf, Tanko</creator><creator>Bako, Ibrahim Gaya</creator><creator>Malgwi, Ibrahim Samaila</creator><creator>Eze, Ejike Daniel</creator><creator>Ali, Zubairu</creator><creator>Aliyu, Mohammed</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9119-8870</orcidid><orcidid>https://orcid.org/0000-0002-0459-2141</orcidid><orcidid>https://orcid.org/0000-0002-9348-3966</orcidid></search><sort><creationdate>20240801</creationdate><title>Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate</title><author>Emmanuel, Nachamada Solomon ; 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Thus, this study evaluated some novel preliminary changes in renal hormonal receptors, the aquaporin-3 channel, oxidative stress markers, and hematological indices induced by monosodium glutamate in lactating rats. Post-parturition, twenty-four (24) lactating Wistar rats were divided into four (4) groups of six rats each (
n
= 6). Oral administration of distilled water and MSG started three (3) days postpartum as follows: group 1: distilled water (1 ml/kg BW), group 2: MSG (925 mg/kg BW), group 3: MSG (1850 mg/kg BW), and group 4: MSG (3700 mg/kg BW). At the end of the experiment, which lasted fourteen (14) days, animals were sacrificed and samples of blood and tissues were obtained for biochemical analysis. MSG administration significantly (
p
< 0.05) increased ROS and MDA, with a significant (
p
< 0.05) decrease in kidney antioxidants. Serum creatinine, total, conjugated, and unconjugated bilirubin significantly (
p
< 0.05) increased with MSG administration. The prolactin receptor was significantly reduced (
p
< 0.05), while the oxytocin receptor and aquaporin-3 channel were significantly (
p
< 0.05) increased in the MSG-administered groups. There were significant (
p
< 0.05) changes in the hematological indices of the MSG-administered animals. Thus, the findings of this study suggest that high MSG consumption causes hematological alterations and may alter renal function via increased ROS production and dysregulation of the AQP-3 channel, prolactin, and oxytocin receptors in the kidneys of lactating Wistar rats.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38446217</pmid><doi>10.1007/s00210-024-03008-8</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-9119-8870</orcidid><orcidid>https://orcid.org/0000-0002-0459-2141</orcidid><orcidid>https://orcid.org/0000-0002-9348-3966</orcidid></addata></record> |
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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2024-08, Vol.397 (8), p.6213-6229 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Aquaporin 3 - metabolism Aquaporins Bilirubin Biochemical analysis Biomedical and Life Sciences Biomedicine Creatinine Female Hematology Hormones Kidney - drug effects Kidney - metabolism Kidneys Lactation Monosodium glutamate Neurosciences Oral administration Oxidative stress Oxidative Stress - drug effects Oxytocin Oxytocin receptors Parturition Pharmacology/Toxicology Prolactin Prolactin - blood Prolactin - metabolism Rats Rats, Wistar Receptor mechanisms Receptors, Oxytocin - metabolism Renal function Sodium Glutamate - toxicity |
| title | Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate |
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