Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance

Perioperative neurocognitive disorders (PND) refer to cognitive deterioration that occurs after surgery or anesthesia. Prolonged isoflurane exposure has potential neurotoxicity and induces PND, but the mechanism is unclear. The glymphatic system clears harmful metabolic waste from the brain. This st...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2024-08, Vol.44 (8), p.1450-1466
Hauptverfasser:	Dong, Rui, Han, Yuqiang, Lv, Pin, Jiang, Linhao, Wang, Zimo, Peng, Liangyu, Liu, Shuai, Ma, Zhengliang, Xia, Tianjiao, Zhang, Bing, Gu, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - adverse effects Anesthetics, Inhalation - pharmacology Animals Aquaporin 4 - metabolism Cognitive Dysfunction - chemically induced Cognitive Dysfunction - metabolism Glymphatic System - metabolism Hippocampus - drug effects Hippocampus - metabolism Isoflurane - pharmacology Male Mice Mice, Inbred C57BL
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