Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model
Purpose The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA mode...
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| Veröffentlicht in: | Neuroradiology 2024-05, Vol.66 (5), p.825-834 |
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| creator | Won, Dong-Sung Lee, Ki Baek Park, Jung-Hoon Zeng, Chu Hui Kim, Mi Hyeon Lee, Deok Hee |
| description | Purpose
The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated.
Methods
Male New Zealand White rabbits (
N
= 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck (
D
/
N
) ratio, and histologic parameters were compared among the groups.
Results
Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all
P
|
| doi_str_mv | 10.1007/s00234-024-03326-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2937705929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3041672543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-bfd17f4280d90a76b9bdbb0d1019ae85de12f0fba8f3618aa124a617ee41a1a33</originalsourceid><addsrcrecordid>eNp9kL1PHDEQxS0UBMeFfyAFspSGxsn449a7ZYICREJKA0Uqa7yeJQv7cbF3Fe6_x8cBkSgoRlO837x5eox9kvBFAtivCUBpI0Dl0VoV4mGPLaTRSshKwQe2yHopdGXgkB2ldAcA2mp7wA51aXRZaFiw39-x68Zx4APV92LdYZo2fBp5HQkn4sj_tYHEVqTAcaA5blLP24FPf4jTFsdEoh3CXGcgovftxPsxUPeR7TfYJTp-3kt2c_7j-uxSXP26-Hn27UrUOfIkfBOkbYwqIVSAtvCVD95DkCArpHIVSKoGGo9lowtZIkplsJCWyEiUqPWSne5813H8O1OaXN-mmroupx3n5FSlrYVVlfeSfX6D3o1zHHI6p8HIwqqV2RqqHVXHMaVIjVvHtse4cRLctni3K97l4t1T8e4hH508W8--p_B68tJ0BvQOSFkabin-__2O7SNlHo5q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3041672543</pqid></control><display><type>article</type><title>Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Won, Dong-Sung ; Lee, Ki Baek ; Park, Jung-Hoon ; Zeng, Chu Hui ; Kim, Mi Hyeon ; Lee, Deok Hee</creator><creatorcontrib>Won, Dong-Sung ; Lee, Ki Baek ; Park, Jung-Hoon ; Zeng, Chu Hui ; Kim, Mi Hyeon ; Lee, Deok Hee</creatorcontrib><description>Purpose
The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated.
Methods
Male New Zealand White rabbits (
N
= 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck (
D
/
N
) ratio, and histologic parameters were compared among the groups.
Results
Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all
P
< .05).
D
/
N
ratio was significantly lower in groups B and C compared to group A (all
P
< .05). Additionally, tunica media thickness, vessel area, and luminal area were significantly greater in groups B and C compared to group A (all
P
< .05). These variables were found to be significantly greater in group B compared to group C (all
P
< .05).
Conclusion
The creation of a wide-necked aneurysm using balloon neck-plasty after elastase induction in rabbits has been determined to be technically feasible and safe.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-024-03326-x</identifier><identifier>PMID: 38438630</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aneurysm ; Aneurysms ; Animals ; Area ; Balloon treatment ; Balloons ; Carotid arteries ; Carotid artery ; Carotid Artery, Common ; Diameters ; Disease Models, Animal ; Elastase ; Feasibility studies ; Imaging ; Interventional Neuroradiology ; Intracranial Aneurysm - pathology ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Pancreatic Elastase - adverse effects ; Rabbits ; Radiology ; Saccule ; Surgery ; Technology assessment</subject><ispartof>Neuroradiology, 2024-05, Vol.66 (5), p.825-834</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-bfd17f4280d90a76b9bdbb0d1019ae85de12f0fba8f3618aa124a617ee41a1a33</cites><orcidid>0000-0003-0355-0449 ; 0000-0001-8856-8335 ; 0000-0003-3021-1151 ; 0000-0002-6953-0582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00234-024-03326-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00234-024-03326-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38438630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Won, Dong-Sung</creatorcontrib><creatorcontrib>Lee, Ki Baek</creatorcontrib><creatorcontrib>Park, Jung-Hoon</creatorcontrib><creatorcontrib>Zeng, Chu Hui</creatorcontrib><creatorcontrib>Kim, Mi Hyeon</creatorcontrib><creatorcontrib>Lee, Deok Hee</creatorcontrib><title>Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><addtitle>Neuroradiology</addtitle><description>Purpose
The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated.
Methods
Male New Zealand White rabbits (
N
= 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck (
D
/
N
) ratio, and histologic parameters were compared among the groups.
Results
Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all
P
< .05).
D
/
N
ratio was significantly lower in groups B and C compared to group A (all
P
< .05). Additionally, tunica media thickness, vessel area, and luminal area were significantly greater in groups B and C compared to group A (all
P
< .05). These variables were found to be significantly greater in group B compared to group C (all
P
< .05).
Conclusion
The creation of a wide-necked aneurysm using balloon neck-plasty after elastase induction in rabbits has been determined to be technically feasible and safe.</description><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Animals</subject><subject>Area</subject><subject>Balloon treatment</subject><subject>Balloons</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Artery, Common</subject><subject>Diameters</subject><subject>Disease Models, Animal</subject><subject>Elastase</subject><subject>Feasibility studies</subject><subject>Imaging</subject><subject>Interventional Neuroradiology</subject><subject>Intracranial Aneurysm - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Pancreatic Elastase - adverse effects</subject><subject>Rabbits</subject><subject>Radiology</subject><subject>Saccule</subject><subject>Surgery</subject><subject>Technology assessment</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1PHDEQxS0UBMeFfyAFspSGxsn449a7ZYICREJKA0Uqa7yeJQv7cbF3Fe6_x8cBkSgoRlO837x5eox9kvBFAtivCUBpI0Dl0VoV4mGPLaTRSshKwQe2yHopdGXgkB2ldAcA2mp7wA51aXRZaFiw39-x68Zx4APV92LdYZo2fBp5HQkn4sj_tYHEVqTAcaA5blLP24FPf4jTFsdEoh3CXGcgovftxPsxUPeR7TfYJTp-3kt2c_7j-uxSXP26-Hn27UrUOfIkfBOkbYwqIVSAtvCVD95DkCArpHIVSKoGGo9lowtZIkplsJCWyEiUqPWSne5813H8O1OaXN-mmroupx3n5FSlrYVVlfeSfX6D3o1zHHI6p8HIwqqV2RqqHVXHMaVIjVvHtse4cRLctni3K97l4t1T8e4hH508W8--p_B68tJ0BvQOSFkabin-__2O7SNlHo5q</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Won, Dong-Sung</creator><creator>Lee, Ki Baek</creator><creator>Park, Jung-Hoon</creator><creator>Zeng, Chu Hui</creator><creator>Kim, Mi Hyeon</creator><creator>Lee, Deok Hee</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0355-0449</orcidid><orcidid>https://orcid.org/0000-0001-8856-8335</orcidid><orcidid>https://orcid.org/0000-0003-3021-1151</orcidid><orcidid>https://orcid.org/0000-0002-6953-0582</orcidid></search><sort><creationdate>20240501</creationdate><title>Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model</title><author>Won, Dong-Sung ; Lee, Ki Baek ; Park, Jung-Hoon ; Zeng, Chu Hui ; Kim, Mi Hyeon ; Lee, Deok Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-bfd17f4280d90a76b9bdbb0d1019ae85de12f0fba8f3618aa124a617ee41a1a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aneurysm</topic><topic>Aneurysms</topic><topic>Animals</topic><topic>Area</topic><topic>Balloon treatment</topic><topic>Balloons</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Carotid Artery, Common</topic><topic>Diameters</topic><topic>Disease Models, Animal</topic><topic>Elastase</topic><topic>Feasibility studies</topic><topic>Imaging</topic><topic>Interventional Neuroradiology</topic><topic>Intracranial Aneurysm - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Pancreatic Elastase - adverse effects</topic><topic>Rabbits</topic><topic>Radiology</topic><topic>Saccule</topic><topic>Surgery</topic><topic>Technology assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won, Dong-Sung</creatorcontrib><creatorcontrib>Lee, Ki Baek</creatorcontrib><creatorcontrib>Park, Jung-Hoon</creatorcontrib><creatorcontrib>Zeng, Chu Hui</creatorcontrib><creatorcontrib>Kim, Mi Hyeon</creatorcontrib><creatorcontrib>Lee, Deok Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won, Dong-Sung</au><au>Lee, Ki Baek</au><au>Park, Jung-Hoon</au><au>Zeng, Chu Hui</au><au>Kim, Mi Hyeon</au><au>Lee, Deok Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><addtitle>Neuroradiology</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>66</volume><issue>5</issue><spage>825</spage><epage>834</epage><pages>825-834</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><abstract>Purpose
The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated.
Methods
Male New Zealand White rabbits (
N
= 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck (
D
/
N
) ratio, and histologic parameters were compared among the groups.
Results
Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all
P
< .05).
D
/
N
ratio was significantly lower in groups B and C compared to group A (all
P
< .05). Additionally, tunica media thickness, vessel area, and luminal area were significantly greater in groups B and C compared to group A (all
P
< .05). These variables were found to be significantly greater in group B compared to group C (all
P
< .05).
Conclusion
The creation of a wide-necked aneurysm using balloon neck-plasty after elastase induction in rabbits has been determined to be technically feasible and safe.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38438630</pmid><doi>10.1007/s00234-024-03326-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0355-0449</orcidid><orcidid>https://orcid.org/0000-0001-8856-8335</orcidid><orcidid>https://orcid.org/0000-0003-3021-1151</orcidid><orcidid>https://orcid.org/0000-0002-6953-0582</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroradiology, 2024-05, Vol.66 (5), p.825-834 |
| issn | 0028-3940 1432-1920 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aneurysm Aneurysms Animals Area Balloon treatment Balloons Carotid arteries Carotid artery Carotid Artery, Common Diameters Disease Models, Animal Elastase Feasibility studies Imaging Interventional Neuroradiology Intracranial Aneurysm - pathology Male Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Pancreatic Elastase - adverse effects Rabbits Radiology Saccule Surgery Technology assessment |
| title | Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model |
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