Simultaneous analysis of acyclovir and its metabolite using hydrophilic interaction liquid chromatography-tandem mass spectrometry

The antiviral drug acyclovir (ACV) may induce drug-induced neuropsychiatric symptoms as side effects. The detailed pathogenic mechanism remains unclear; however, it is hypothesized that 9-carboxymethoxymethylguanine (CMMG), a metabolite of ACV, is the causative compound. Therefore, the blood concent...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of analytical toxicology 2024-05, Vol.48 (4), p.204-209
Hauptverfasser:	Takeda, Saki, Ueno, Satoshi, Zenda, Rie, Muto, Kazuya, Iseki, Ken, Harada, Kazuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - blood Antiviral Agents - blood Chromatography, Liquid Guanine - analogs & derivatives Guanine - blood Humans Hydrophobic and Hydrophilic Interactions Limit of Detection Linear Models Reproducibility of Results Tandem Mass Spectrometry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!