Investigation of Siderophore–Platinum(IV) Conjugates Reveals Differing Antibacterial Activity and DNA Damage Depending on the Platinum Cargo

The growing threat of bacterial infections coupled with the dwindling arsenal of effective antibiotics has heightened the urgency for innovative strategies to combat bacterial pathogens, particularly Gram-negative strains, which pose a significant challenge due to their outer membrane permeability b...

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Veröffentlicht in:	ACS infectious diseases 2024-04, Vol.10 (4), p.1250-1266
Hauptverfasser:	Guo, Chuchu, Wang, Kwo-Kwang A., Nolan, Elizabeth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology DNA Damage Enterobactin Escherichia coli Humans Oxaliplatin - pharmacology Platinum - pharmacology Siderophores - pharmacology
Online-Zugang:	Volltext
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