Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration

An adverse effect of drug candidates, seizure is a serious issue in drug development. Improving evaluation systems for seizure liability is crucial for selecting good candidates. Firstly, in vitro electrophysiological measurement by a multielectrode array system in rat hippocampal brain slices was e...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2024-03, Vol.126, p.107496-107496, Article 107496
Hauptverfasser:	Tsubouchi, Tadashi, Ikeda, Keigo, Sasaki, Yasuhiro, Watanabe, Hitoshi, Chihara, Kazuhiro, Miyawaki, Izuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain slice Convulsion Intracerebroventricular administration Mouse Multielectrode Population spike Rat Screening Seizure
Online-Zugang:	Volltext
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