CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice

DNA double-strand breaks (DSBs) contribute to genome instability, a key feature of cancer. DSBs are mainly repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). We investigated the role of an isoform of the multifunctional cyclin-dependent kinase 9, CDK9-55, in DNA repair,...

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Veröffentlicht in:	Oncogene 2024-04, Vol.43 (17), p.1263-1273
Hauptverfasser:	Alfano, Luigi, Iannuzzi, Carmelina Antonella, Barone, Daniela, Forte, Iris Maria, Ragosta, Maria Carmen, Cuomo, Maria, Mazzarotti, Giulio, Dell’Aquila, Milena, Altieri, Angela, Caporaso, Antonella, Roma, Cristin, Marra, Laura, Boffo, Silvia, Indovina, Paola, De Laurentiis, Michelino, Giordano, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 14/19 631/337/1427/2122 631/337/1427/2190 82/29 82/58 Adenomatous polyposis coli Anaphase Anaphase-promoting complex Apoptosis Camptothecin Cancer Cancer therapies Cell Biology Cell cycle Cell division Cloning CRISPR Cyclin-dependent kinase Cyclin-dependent kinase 9 Cyclin-dependent kinases DNA damage DNA repair Genomes Genomic instability Homologous recombination Human Genetics Internal Medicine Kinases Medical research Medicine Medicine & Public Health Non-homologous end joining Oncology Phosphorylation Proteins Software Ubiquitin-protein ligase
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