Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery

The Son of Sevenless 1 (SOS1) guanine nucleotide exchange factor, prevalent across eukaryotic species, plays a pivotal role in facilitating the attachment of RAS protein to GTP, thereby regulating the activation of intracellular RAS proteins. This regulation is part of a feedback mechanism involving...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-03, Vol.268, p.116282-116282, Article 116282
Hauptverfasser:	Wu, Jialin, Li, Xiaoxue, Wu, Chengyong, Wang, Yuxi, Zhang, Jifa
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator Catalytic Domain Drug Discovery Inhibitor Nuclear Family RAS Signal Transduction SOS1
Online-Zugang:	Volltext
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