Metabolomics of male infertility
•Metabolomics is a potential technique for the investigation of male infertility.•Metabolomics has shown potential as a prognostic and predictive tool for male infertility therapies.•Metabolomics is useful in the identification of targeted treatments for male infertility.•Further research is needed...
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| Veröffentlicht in: | Clinica chimica acta 2024-03, Vol.556, p.117850-117850, Article 117850 |
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| container_title | Clinica chimica acta |
| container_volume | 556 |
| creator | Victor Oluwaloseyi, Amos Aduragbemi Noah, Odeyemi Lydia Oluwatoyin, Ajayi Gaffar, Yusuff Moses, Olotu Oyedayo Phillips, Akano Comfort Onaolapo, Moyinoluwa Sylvester Olateju, Bolade Ademola Ayodele, Adelakun Mega Obukohwo, Oyowvi Ayodeji Folorunsho, Ajayi |
| description | •Metabolomics is a potential technique for the investigation of male infertility.•Metabolomics has shown potential as a prognostic and predictive tool for male infertility therapies.•Metabolomics is useful in the identification of targeted treatments for male infertility.•Further research is needed to fully realize the potential of metabolomics in the diagnosis and treatment of male infertility.
This review explores the use of metabolomics in male infertility. Metabolomics, an evolving omics technology that targets the products of cellular metabolism, is valuable for elucidating underlying pathophysiology of many disorders including male infertility. The identification of reliable biomarkers is essential for accurate diagnosis and for developing precision therapeutics for those afflicted by reproductive dysfunction. Unfortunately, despite significant progress to date, the intricate relationships between these metabolic pathways and male infertility remain elusive. It is clear, however, that additional research is required to more fully characterize the role of metabolomics in this disorder and in the potential development of targeted therapies for precision medicine. |
| doi_str_mv | 10.1016/j.cca.2024.117850 |
| format | Article |
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This review explores the use of metabolomics in male infertility. Metabolomics, an evolving omics technology that targets the products of cellular metabolism, is valuable for elucidating underlying pathophysiology of many disorders including male infertility. The identification of reliable biomarkers is essential for accurate diagnosis and for developing precision therapeutics for those afflicted by reproductive dysfunction. Unfortunately, despite significant progress to date, the intricate relationships between these metabolic pathways and male infertility remain elusive. It is clear, however, that additional research is required to more fully characterize the role of metabolomics in this disorder and in the potential development of targeted therapies for precision medicine.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2024.117850</identifier><identifier>PMID: 38431200</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Diagnosis ; Infertility ; Male reproductive function ; Metabolomics ; Therapy</subject><ispartof>Clinica chimica acta, 2024-03, Vol.556, p.117850-117850, Article 117850</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-508414c0750515170b926e3b780309335ad2d83c1ccbb3edb5f55e3d45d957c3</citedby><cites>FETCH-LOGICAL-c353t-508414c0750515170b926e3b780309335ad2d83c1ccbb3edb5f55e3d45d957c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2024.117850$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38431200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Victor Oluwaloseyi, Amos</creatorcontrib><creatorcontrib>Aduragbemi Noah, Odeyemi</creatorcontrib><creatorcontrib>Lydia Oluwatoyin, Ajayi</creatorcontrib><creatorcontrib>Gaffar, Yusuff</creatorcontrib><creatorcontrib>Moses, Olotu</creatorcontrib><creatorcontrib>Oyedayo Phillips, Akano</creatorcontrib><creatorcontrib>Comfort Onaolapo, Moyinoluwa</creatorcontrib><creatorcontrib>Sylvester Olateju, Bolade</creatorcontrib><creatorcontrib>Ademola Ayodele, Adelakun</creatorcontrib><creatorcontrib>Mega Obukohwo, Oyowvi</creatorcontrib><creatorcontrib>Ayodeji Folorunsho, Ajayi</creatorcontrib><title>Metabolomics of male infertility</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>•Metabolomics is a potential technique for the investigation of male infertility.•Metabolomics has shown potential as a prognostic and predictive tool for male infertility therapies.•Metabolomics is useful in the identification of targeted treatments for male infertility.•Further research is needed to fully realize the potential of metabolomics in the diagnosis and treatment of male infertility.
This review explores the use of metabolomics in male infertility. Metabolomics, an evolving omics technology that targets the products of cellular metabolism, is valuable for elucidating underlying pathophysiology of many disorders including male infertility. The identification of reliable biomarkers is essential for accurate diagnosis and for developing precision therapeutics for those afflicted by reproductive dysfunction. Unfortunately, despite significant progress to date, the intricate relationships between these metabolic pathways and male infertility remain elusive. It is clear, however, that additional research is required to more fully characterize the role of metabolomics in this disorder and in the potential development of targeted therapies for precision medicine.</description><subject>Diagnosis</subject><subject>Infertility</subject><subject>Male reproductive function</subject><subject>Metabolomics</subject><subject>Therapy</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQQBdRbK3-AC-So5fEmUw22eBJil9Q8dL7kuxOYEvS1N1U6L83JdWjp2HgzYN5QtwiJAiYP2wSY6okhTRLEAsl4UzMURUUU1am52IOAGWsSoUzcRXCZlwzyPFSzEhlhCnAXEQfPFR13_adMyHqm6irWo7ctmE_uNYNh2tx0VRt4JvTXIj1y_N6-RavPl_fl0-r2JCkIZagMswMFBIkSiygLtOcqS4UEJREsrKpVWTQmLomtrVspGSymbSlLAwtxP2k3fn-a89h0J0Lhtu22nK_DzotqRgteZ6PKE6o8X0Inhu9866r_EEj6GMXvdFjF33soqcu483dSb-vO7Z_F78hRuBxAnj88dux18E43hq2zrMZtO3dP_ofNcpwDA</recordid><startdate>20240315</startdate><enddate>20240315</enddate><creator>Victor Oluwaloseyi, Amos</creator><creator>Aduragbemi Noah, Odeyemi</creator><creator>Lydia Oluwatoyin, Ajayi</creator><creator>Gaffar, Yusuff</creator><creator>Moses, Olotu</creator><creator>Oyedayo Phillips, Akano</creator><creator>Comfort Onaolapo, Moyinoluwa</creator><creator>Sylvester Olateju, Bolade</creator><creator>Ademola Ayodele, Adelakun</creator><creator>Mega Obukohwo, Oyowvi</creator><creator>Ayodeji Folorunsho, Ajayi</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240315</creationdate><title>Metabolomics of male infertility</title><author>Victor Oluwaloseyi, Amos ; Aduragbemi Noah, Odeyemi ; Lydia Oluwatoyin, Ajayi ; Gaffar, Yusuff ; Moses, Olotu ; Oyedayo Phillips, Akano ; Comfort Onaolapo, Moyinoluwa ; Sylvester Olateju, Bolade ; Ademola Ayodele, Adelakun ; Mega Obukohwo, Oyowvi ; Ayodeji Folorunsho, Ajayi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-508414c0750515170b926e3b780309335ad2d83c1ccbb3edb5f55e3d45d957c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Diagnosis</topic><topic>Infertility</topic><topic>Male reproductive function</topic><topic>Metabolomics</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Victor Oluwaloseyi, Amos</creatorcontrib><creatorcontrib>Aduragbemi Noah, Odeyemi</creatorcontrib><creatorcontrib>Lydia Oluwatoyin, Ajayi</creatorcontrib><creatorcontrib>Gaffar, Yusuff</creatorcontrib><creatorcontrib>Moses, Olotu</creatorcontrib><creatorcontrib>Oyedayo Phillips, Akano</creatorcontrib><creatorcontrib>Comfort Onaolapo, Moyinoluwa</creatorcontrib><creatorcontrib>Sylvester Olateju, Bolade</creatorcontrib><creatorcontrib>Ademola Ayodele, Adelakun</creatorcontrib><creatorcontrib>Mega Obukohwo, Oyowvi</creatorcontrib><creatorcontrib>Ayodeji Folorunsho, Ajayi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Victor Oluwaloseyi, Amos</au><au>Aduragbemi Noah, Odeyemi</au><au>Lydia Oluwatoyin, Ajayi</au><au>Gaffar, Yusuff</au><au>Moses, Olotu</au><au>Oyedayo Phillips, Akano</au><au>Comfort Onaolapo, Moyinoluwa</au><au>Sylvester Olateju, Bolade</au><au>Ademola Ayodele, Adelakun</au><au>Mega Obukohwo, Oyowvi</au><au>Ayodeji Folorunsho, Ajayi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomics of male infertility</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2024-03-15</date><risdate>2024</risdate><volume>556</volume><spage>117850</spage><epage>117850</epage><pages>117850-117850</pages><artnum>117850</artnum><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>•Metabolomics is a potential technique for the investigation of male infertility.•Metabolomics has shown potential as a prognostic and predictive tool for male infertility therapies.•Metabolomics is useful in the identification of targeted treatments for male infertility.•Further research is needed to fully realize the potential of metabolomics in the diagnosis and treatment of male infertility.
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| ispartof | Clinica chimica acta, 2024-03, Vol.556, p.117850-117850, Article 117850 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2937335666 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Diagnosis Infertility Male reproductive function Metabolomics Therapy |
| title | Metabolomics of male infertility |
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