Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach

In vitro methods are widely used in modern toxicological testing; however, the data cannot be directly employed for risk assessment. In vivo toxicity of chemicals can be predicted from in vitro data using physiologically based toxicokinetic (PBTK) modelling-facilitated reverse dosimetry (PBTK-RD). I...

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Veröffentlicht in:	Toxicology and applied pharmacology 2024-03, Vol.484, p.116879-116879, Article 116879
Hauptverfasser:	Bhateria, Manisha, Taneja, Isha, Karsauliya, Kajal, Sonker, Ashish Kumar, Shibata, Yukihiro, Sato, Hiromi, Singh, Sheelendra Pratap, Hisaka, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Developmental toxicity Fungicides Health risk assessment Humans Models, Biological Monte Carlo Method Monte Carlo simulations PBTK model Pyrimidines Rats Risk Assessment Toxicokinetics Uncertainty factor
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