Internal absorbed dose calculation in body organs due to injection of Rhenium-188 labeled to Mu-9 antibody

The use of radiopharmaceuticals has gained a special place in the diagnosis and treatment of cancers and evaluation of the function of different organs of the body. In this study, the absorbed dose distribution of organs after injection of 188Re-Mu-9 has been investigated using MIRD method and MCNP-4C simulation code. The 188Re-Mu-9 labeled was injected the mouse body and the amount of 188Re-labeled accumulation was evaluated after 1, 4 and 2 4 h. Having a map of the distribution of radiopharmaceutical activity in the animal body, it is possible to convert it into a human model to obtain the internal dose received by 188Re-Mu-9 injection using the MIRD calculation method and the MCNP simulation code. According to the results of the study, the animal/human model can be acceptable method for dose estimation of antibody-based radiopharmaceuticals. •Aim of this method is to deliver more radiation doses into tumoral cells than normal cells.•The absorbed dose distribution of organs after injection of 188Re-Mu-9 has been investigated.•MIRD and MCNP-4C simulation code are used for estimation of dose.•The 188Re-Mu-9 was injected the mouse body and the of 188Re-labeled accumulation in was evaluated after 1, 4 and 24 h.•The result showed that the effective dose of different organs was obtained from the data of mouse in 1MBq activity.