Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice

Intravenously administered chemotherapeutic cabazitaxel is used for palliative treatment of prostate cancer. An oral formulation would be more patient-friendly and reduce the need for hospitalization. We therefore study determinants of the oral pharmacokinetics of cabazitaxel in a ritonavir-boosted...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmaceutics 2024-04, Vol.21 (4), p.1952-1964
Hauptverfasser:	Loos, Nancy H.C., Ferreira Martins, Margarida L., Rijmers, Jamie, de Jong, Daniëlle, Lebre, Maria C., Tibben, Matthijs, Beijnen, Jos H., Schinkel, Alfred H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anions - metabolism Carboxylesterase - metabolism Docetaxel Humans Liver - metabolism Liver-Specific Organic Anion Transporter 1 - metabolism Male Mice Mice, Transgenic Organic Anion Transporters - metabolism Organic Anion Transporters, Sodium-Independent - metabolism Peptides - metabolism Ritonavir Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism Taxoids
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!