Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and GABAergic neuronal systems in Caenorhabditis elegans

6-PPD quinone (6-PPDQ), an emerging environmental pollutant, is converted based on 6-PPD via ozonation. However, a systematic evaluation on possible neurotoxicity of long-term and low-dose 6-PPDQ exposure and the underlying mechanism remain unknown. In the present work, 0.1–10 μg/L 6-PPDQ was added...

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Veröffentlicht in:	The Science of the total environment 2024-04, Vol.922, p.171291-171291, Article 171291
Hauptverfasser:	Liu, Huanliang, Tan, Xiaochao, Wu, Yu, Li, Xiaona, Hu, Zhiyong, Lei, Shuhan, Fan, Wendong, Wang, Zhenyu
Format:	Artikel
Sprache:	eng
Schlagworte:	6-PPDQ Animals Benzoquinones - metabolism Caenorhabditis elegans Dopamine GABAergic Neurons - metabolism Molecular Docking Simulation Neuron damage Neurotoxicity Neurotransmission Neurotransmitter Agents - metabolism Sensory perception behavior
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