Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice

Expansion of follicular helper T (Tfh) cells and abnormal glucose metabolism are present in patients with systemic lupus erythematosus (SLE). Pyruvate kinase M2 (PKM2) is one of the key glycolytic enzymes, and the underlying mechanism of PKM2-mediated Tfh cell glycolysis in SLE pathogenesis remains...

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Veröffentlicht in:	Journal of autoimmunity 2024-05, Vol.145, p.103198, Article 103198
Hauptverfasser:	Lin, Manna, Huang, Liuting, Huang, Junxia, Yu, Jia, Yang, Xue, Yang, Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Disease Models, Animal Female Follicular helper T cells Glycolysis Humans Inflammation - immunology Inflammation - metabolism Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Mice Mice, Inbred MRL lpr PKM2 Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - metabolism Pyruvate Kinase - metabolism Signal Transduction Systemic lupus erythematosus T Follicular Helper Cells - immunology T Follicular Helper Cells - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism
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