Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response

Collective cell migration is integral to many developmental and disease processes. Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective migration in the Drosophila ovary. We now report that the Pp1 phosphatase regulatory subunit dPPP1R15 is a critical regulator...

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Veröffentlicht in:	Current biology 2024-04, Vol.34 (7), p.1390-1402.e4
Hauptverfasser:	Chen, Yujun, McDonald, Jocelyn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis cell migration Cell Movement cell protrusions development eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoplasmic Reticulum Stress - physiology Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism integrated stress response Mammals oogenesis Phosphoric Monoester Hydrolases - metabolism Signal Transduction
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