Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer

Ferritinophagy is a cellular process to release redox-active iron. Excessive activation of ferritinophagy ultimately results in ferroptosis characterized by ROS accumulation which plays important roles in the development and progression of cancer. Sinomenine, a main bioactive alkaloid from the tradi...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-03, Vol.268, p.116250-116250, Article 116250
Hauptverfasser:	Zhu, Ling, Chen, Chen, Cai, Yuxing, Li, Yalin, Gong, Lijie, Zhu, Tianyu, Kong, Lingyi, Luo, Jianguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Colorectal cancer Colorectal Neoplasms - drug therapy Ferritinophagy Ferritins FTH1-NCOA4 protein-protein interaction Humans Iron - metabolism Lipid ROS Morphinans Reactive Oxygen Species - metabolism Sinomenine derivatives
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