The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases
Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be clas...
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| Veröffentlicht in: | The American journal of pathology 2024-06, Vol.194 (6), p.879-893 |
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| container_title | The American journal of pathology |
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| creator | Zhang, Yudian Liu, Ying Huo, Wen He, Longfei Li, Bowen Wang, Hui Meng, Fanyin Duan, Chenggang Zhou, Bingru Wu, Jinbo Chen, Rong Xing, Juan Wan, Ying |
| description | Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis, according to the location of occurrence. The etiology of cholestatic liver diseases is complex, and includes drugs, poisons, viruses, parasites, bacteria, autoimmune responses, tumors, and genetic metabolism. The pathogenesis of cholelstatic liver disease is not completely clarified, and effective therapy is lacking. Clarifying its mechanism to find more effective therapeutic targets and drugs is an unmet need. Increasing evidence demonstrates that miRNA and long noncoding RNA are involved in the progression of cholestatic liver diseases. This review provides a comprehensive summary of the research progress on the roles of miRNA and long noncoding RNA in cholestatic liver diseases. The aim of the review is to enhance the understanding of their potential diagnostic, therapeutic, and prognostic value for patients with cholestasis. |
| doi_str_mv | 10.1016/j.ajpath.2024.02.006 |
| format | Article |
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These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis, according to the location of occurrence. The etiology of cholestatic liver diseases is complex, and includes drugs, poisons, viruses, parasites, bacteria, autoimmune responses, tumors, and genetic metabolism. The pathogenesis of cholelstatic liver disease is not completely clarified, and effective therapy is lacking. Clarifying its mechanism to find more effective therapeutic targets and drugs is an unmet need. Increasing evidence demonstrates that miRNA and long noncoding RNA are involved in the progression of cholestatic liver diseases. This review provides a comprehensive summary of the research progress on the roles of miRNA and long noncoding RNA in cholestatic liver diseases. The aim of the review is to enhance the understanding of their potential diagnostic, therapeutic, and prognostic value for patients with cholestasis.</description><identifier>ISSN: 0002-9440</identifier><identifier>ISSN: 1525-2191</identifier><identifier>EISSN: 1525-2191</identifier><identifier>DOI: 10.1016/j.ajpath.2024.02.006</identifier><identifier>PMID: 38417698</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cholestasis - genetics ; Cholestasis - metabolism ; Cholestasis - pathology ; Humans ; Liver Diseases - genetics ; Liver Diseases - metabolism ; Liver Diseases - pathology ; MicroRNAs - genetics ; MicroRNAs - metabolism ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism</subject><ispartof>The American journal of pathology, 2024-06, Vol.194 (6), p.879-893</ispartof><rights>2024 American Society for Investigative Pathology</rights><rights>Copyright © 2024 American Society for Investigative Pathology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c357t-7111eb8e4582708d62d11106857b8bddeae45f049e27db00dd6f97e8827ab1eb3</cites><orcidid>0000-0001-5909-2892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002944024000750$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38417698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yudian</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Huo, Wen</creatorcontrib><creatorcontrib>He, Longfei</creatorcontrib><creatorcontrib>Li, Bowen</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Meng, Fanyin</creatorcontrib><creatorcontrib>Duan, Chenggang</creatorcontrib><creatorcontrib>Zhou, Bingru</creatorcontrib><creatorcontrib>Wu, Jinbo</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Xing, Juan</creatorcontrib><creatorcontrib>Wan, Ying</creatorcontrib><title>The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis, according to the location of occurrence. The etiology of cholestatic liver diseases is complex, and includes drugs, poisons, viruses, parasites, bacteria, autoimmune responses, tumors, and genetic metabolism. The pathogenesis of cholelstatic liver disease is not completely clarified, and effective therapy is lacking. Clarifying its mechanism to find more effective therapeutic targets and drugs is an unmet need. Increasing evidence demonstrates that miRNA and long noncoding RNA are involved in the progression of cholestatic liver diseases. This review provides a comprehensive summary of the research progress on the roles of miRNA and long noncoding RNA in cholestatic liver diseases. The aim of the review is to enhance the understanding of their potential diagnostic, therapeutic, and prognostic value for patients with cholestasis.</description><subject>Animals</subject><subject>Cholestasis - genetics</subject><subject>Cholestasis - metabolism</subject><subject>Cholestasis - pathology</subject><subject>Humans</subject><subject>Liver Diseases - genetics</subject><subject>Liver Diseases - metabolism</subject><subject>Liver Diseases - pathology</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><issn>0002-9440</issn><issn>1525-2191</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFLwzAQgIMobk7_gUgefWm9pGmbvghjOhXKhDGfQ9pcXcbWzKYb-O_N2PTRp8tdvrtLPkJuGcQMWPawivVqq_tlzIGLGHgMkJ2RIUt5GnFWsHMyBAAeFULAgFx5vwpplki4JINECpZnhRyS6WKJdO7WSF1DN3Y-G1PdGlq69pPOXFs7Y8PpULYtnSwD6Hvd25qWdo8dfbIetUd_TS4avfZ4c4oj8jF9Xkxeo_L95W0yLqM6SfM-yhljWEkUqeQ5SJNxEyqQyTSvZGUM6nDVgCiQ56YCMCZrihxloHUVOpMRuT_O3XbuaxfeojbW17he6xbdziteJInIRJgfUHFE685532Gjtp3d6O5bMVAHg2qljgbVwaACrg5-RuTutGFXbdD8Nf0qC8DjEcDwz73FTvnaYlujsR3WvTLO_r_hB1kpgX8</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Zhang, Yudian</creator><creator>Liu, Ying</creator><creator>Huo, Wen</creator><creator>He, Longfei</creator><creator>Li, Bowen</creator><creator>Wang, Hui</creator><creator>Meng, Fanyin</creator><creator>Duan, Chenggang</creator><creator>Zhou, Bingru</creator><creator>Wu, Jinbo</creator><creator>Chen, Rong</creator><creator>Xing, Juan</creator><creator>Wan, Ying</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5909-2892</orcidid></search><sort><creationdate>202406</creationdate><title>The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases</title><author>Zhang, Yudian ; Liu, Ying ; Huo, Wen ; He, Longfei ; Li, Bowen ; Wang, Hui ; Meng, Fanyin ; Duan, Chenggang ; Zhou, Bingru ; Wu, Jinbo ; Chen, Rong ; Xing, Juan ; Wan, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7111eb8e4582708d62d11106857b8bddeae45f049e27db00dd6f97e8827ab1eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Cholestasis - genetics</topic><topic>Cholestasis - metabolism</topic><topic>Cholestasis - pathology</topic><topic>Humans</topic><topic>Liver Diseases - genetics</topic><topic>Liver Diseases - metabolism</topic><topic>Liver Diseases - pathology</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yudian</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Huo, Wen</creatorcontrib><creatorcontrib>He, Longfei</creatorcontrib><creatorcontrib>Li, Bowen</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Meng, Fanyin</creatorcontrib><creatorcontrib>Duan, Chenggang</creatorcontrib><creatorcontrib>Zhou, Bingru</creatorcontrib><creatorcontrib>Wu, Jinbo</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Xing, Juan</creatorcontrib><creatorcontrib>Wan, Ying</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yudian</au><au>Liu, Ying</au><au>Huo, Wen</au><au>He, Longfei</au><au>Li, Bowen</au><au>Wang, Hui</au><au>Meng, Fanyin</au><au>Duan, Chenggang</au><au>Zhou, Bingru</au><au>Wu, Jinbo</au><au>Chen, Rong</au><au>Xing, Juan</au><au>Wan, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>2024-06</date><risdate>2024</risdate><volume>194</volume><issue>6</issue><spage>879</spage><epage>893</epage><pages>879-893</pages><issn>0002-9440</issn><issn>1525-2191</issn><eissn>1525-2191</eissn><abstract>Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. 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| subjects | Animals Cholestasis - genetics Cholestasis - metabolism Cholestasis - pathology Humans Liver Diseases - genetics Liver Diseases - metabolism Liver Diseases - pathology MicroRNAs - genetics MicroRNAs - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| title | The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases |
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