Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages

Inflammation is a driver of human disease and an unmet clinical need exists for new anti-inflammatory medicines. As a key cell type in both acute and chronic inflammatory pathologies, macrophages are an appealing therapeutic target for anti-inflammatory medicines. Drug repurposing – the use of exist...

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Veröffentlicht in:	European journal of pharmacology 2024-04, Vol.969, p.176437, Article 176437
Hauptverfasser:	Chaffey, Laura E., Roberti, Annabell, Bowman, Amelia, O'Brien, Conan JO, Som, Liliana, Purvis, Gareth SD, Greaves, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Atherosclerosis Drug Repositioning Drug repurposing Humans Inflammation Inflammation - metabolism Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Macrophage Macrophages Mice NF-kappa B - metabolism NF-κB Sunitinib - pharmacology Tumor Necrosis Factor-alpha - metabolism
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