The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening

[Display omitted] NLRP3 is an intracellular sensor protein that detects a broad range of danger signals and environmental insults. Its activation results in a protective pro-inflammatory response designed to impair pathogens and repair tissue damage via the formation of the NLRP3 inflammasome. Assem...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2024-04, Vol.102, p.129675-129675, Article 129675
Hauptverfasser:	Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen, Wilhelmsen, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammation BAL-0028 CADD DNA-encoded library IL-18 IL-1β NLRP3 inflammasome NLRP3 inhibitor Pyroptosis STAND ATPase
Online-Zugang:	Volltext
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